| 摘要: |
| ［摘要］ 多发性骨髓瘤骨病（MBD）以全身骨质破坏亢进和新骨生成受抑为主要特征，临床表现为骨痛、骨质疏松、病理性骨折以及相关神经压迫症状等。MBD是多发性骨髓瘤（MM）最常见的并发症之一，其发病隐匿，误诊率较高，患者的生存质量及预后较差。该文通过对其发病机制及诊疗进展进行综述，为临床治疗MBD提供参考。 |
| 关键词: 多发性骨髓瘤骨病 破骨细胞活化因子 成骨细胞抑制因子 |
| DOI：10.3969/j.issn.1674-3806.2014.06.31 |
| 分类号:R 68 |
| 基金项目: |
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| Research progress on the pathogenesis，diagnosis and treatment of multiple myeloma bone disease |
|
ZHAO Ning,YAN Dong-xue
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Guangxi Medical College of Guilin, Guangxi 541004,China
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| Abstract: |
| ［Abstract］ The main features of multiple myeloma bone disease(MBD) are hyperactivity of systemic bone destruction and inhibition of new bone formation.Its clinical manifestations include pain, osteoporosis, pathologic fractures and associated nerve compression symptoms etc. MBD is one of the most common complications of multiple myeloma(MM). Its occurrence is occult with higher misdiagnosis rate and patients′quality of life and prognosis are poor. In this article， its pathogenesis,diagnosis and treatment are reviewed, in order to provide reference for clinical treatment of MBD. |
| Key words: Multiple myeloma bone disease（MBD） Osteoclast activating factor Osteoblasts inhibitor |
