| 摘要: |
| ［摘要］ 目的 探讨降钙素原（PCT）对鉴别G-菌、G+菌所致血培养阳性脓毒症的诊断价值。方法 收集2013-01～2014-05在广州市红十字会医院收治的血培养阳性脓毒症患者101例，其中G-菌组56例，G+菌组45例，分别检测患者血清PCT、超敏C反应蛋白(hs-CRP)水平及白细胞（WBC）计数并进行统计学分析，绘制PCT的ROC曲线，分析最佳截断点、敏感度和特异度。结果 G-菌组、G+菌组患者WBC计数和血清hs-CRP水平比较差异均无统计学意义（P>0.05）。G-菌组血清PCT中位数为18 ng/ml，G+菌组为3.6 ng/ml，两组PCT水平比较差异有统计学意义（P<0.05）。通过绘制PCT的ROC曲线，得出曲线下面积AUC为0.864，最佳截断点PCT浓度为3.22 ng/ml,此时敏感度为86%，特异度为72%。结论 PCT在脓毒症中对区分G-菌、G+菌感染有一定的价值，可为临床早期使用抗生素提供参考。 |
| 关键词: 降钙素原 超敏C反应蛋白 白细胞计数 脓毒症 |
| DOI：10.3969/j.issn.1674-3806.2015.01.08 |
| 分类号:R 44 |
| 基金项目: |
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| The value of procalcitonin in the discrimination between sepsis due to different bacterial |
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WANG Yan-shuang, HE Ya-jun
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Clinical Laboratory, Forth Affiliated Hospital of Medical College of Jinan University, Guangzhou Red Cross Hospital, Guangdong 510220, China
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| Abstract: |
| ［Abstract］ Objective To explore the value of procalcitonin(PCT) in the discrimination between sepsis due to Gram-negative（GN） bacteria and duo to Gram-positive（GP） bacteria.Methods One hundred and one sepsis patients with positive blood culture between January 2013 to May 2014 were collected in Guangzhou Red Cross Hospital. Among them, 56 patients were infected with GN bacteria and the other 45 patients were infected with GP bacteria. Serum PCT, hs-CRP and WBC count were detected. Drawing PCT ROC curve aimed to analyze the best cut-off score and the sensitivity and the specificity were made.Results Serum PCT levels were obviously higher in patients with GN bacteria（M=18 ng/ml）than those in patients with GP bacteria（M=3.6 ng/ml）.According to the ROC curve,the best cut off was 3.22 ng/ml with the sensitivity 86% and the specificity 72% and the area under the curve(AUC) was 0.864.Conclusion PCT may be a sensitive index for discrimination between sepsis due to Gram-negative bateria and due to Gram-positive bacteria. |
| Key words: Procalcitonin hs-CRP WBC count Sepsis |
