| 摘要: |
| ［摘要］ 目的 探讨肿瘤性高钙血症患者检测血浆中离子钙(ICa)与总钙(TCa)的临床价值。方法 分别采用离子选择电极法及邻甲酚酞络合酮法对恶性肿瘤患者60例（研究组）和健康对照者50名（对照组）血浆中的ICa和TCa进行检测，计算校正总钙(cTCa)和校正离子钙(nICa)，同时检测并比较血清白蛋白(ALB)及pH值等指标。结果 研究组与对照组TCa水平［(2.41±0.02)mmol/L vs (2.43±0.12)mmol/L]比较差异无统计学意义(P>0.05)；而研究组的cTCa、ICa及nICa水平均高于对照组［(2.56±0.20)mmol/L vs (2.31±0.11)mmol/L，(1.15±0.22)mmol/L vs (1.01±0.30)mmol/L，(1.30±0.11)mmol/L vs (1.18±0.02)mmol/L］，差异有统计学意义(P<0.05)。研究组的ALB水平也低于对照组［(42.21±6.30)g/L vs (55.63±2.51)g/L］，差异有统计学意义(P<0.05)。研究组以nICa>1.35 mmol/L为标准高钙血症检出率［18.33%(11/60)］高于以cTCa>2.70 mmol/L为标准高钙血症检出率［6.67%(4/60)］，差异有统计学意义(χ2=9.458，P=0.036)。结论 在肿瘤性高钙血症的诊断中，ICa具有较高的临床价值，可提高对肿瘤性高钙血症的诊断率。 |
| 关键词: 肿瘤 高钙血症 总钙 离子钙 |
| DOI：10.3969/j.issn.1674-3806.2015.01.14 |
| 分类号:R 730.6 |
| 基金项目: |
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| Clinical significance of plasma ionized calcium and total calcium measurement in the diagnosis of tumor-associated hypercalcemia |
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BI Yan-mei
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Department of Laboratory, General Hospital of Fushun Mining Bureau, Liaoning 113008, China
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| Abstract: |
| ［Abstract］ Objective To evaluate the clinical significance of plasma ionized calcium(ICa)and total calcium(TCa)measurement in the diagnosis of tumor-associated hypercalcemia.Methods The heparin lithium anticoagulated plasma were collected and measured with ion selective electrode(ISE) and orthocresolphthalein complexone(OCPC) method for ICa and TCa in 60 patients with malignant tumor(research group) and 50 healthy people(control group). Plasma albumin and pH value were measured to correct TCa(cTCa) and ICa(nICa).Results The levels of cTCa，ICa and nICa in research group were significantly higher than those in control group ［(2.56±0.20)mmol/L vs (2.31±0.11)mmol/L,(1.15±0.22)mmol/L vs (1.01±0.30)mmol/L and (1.30±0.11)mmol/L vs (1.18±0.02)mmol/L，respectively；(P<0.05)］，but there was no significant difference in TCa between two groups［(2.41±0.02)mmol/L vs (2.43±0.12)mmol/L，(P>0.05)］.In the research group，when taking nICa>1.35 mmol/L or cTCa>2.70 mmol/L as the hypercalcemia critical value，the positive rate of nICa and cTCa were 18.33%(11/60) and 6.67%(4/60)，respectively,the difference was significant(χ2=9.458，P=0.036).Conclusion Determination of ICa may be more clinical meaningful than TCa for tumor-associated hypercalcemia. |
| Key words: Neoplasms Hypercalcemia Total calcium Ionized calcium |
