| 摘要: |
| ［摘要］ 目的 探讨白介素-18（IL-18）及肿瘤坏死因子（TNF-α）在骨性关节炎（OA）发生发展中的临床意义。方法 选取膝关节OA患者71例为OA组，健康成人30名为对照组。采用放射免疫学法检查关节囊滑液中IL-18及TNF-α含量，进行统计学分析。结果 OA组关节滑囊积液中IL-18及TNF-α显著高于对照组,差异有统计学意义(P<0.01)。结论 IL-18及TNF-α参与了关节软骨破坏和滑膜炎症反应的病理过程。 |
| 关键词: 白介素-18 肿瘤坏死因子 关节滑液 膝关节骨性关节炎 |
| DOI：10.3969/j.issn.1674-3806.2015.03.11 |
| 分类号:R 684.3 |
| 基金项目: |
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| Correlation study of osteoarthritis with IL-18 and TNF-α |
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WEI Hai-tao, DONG Le-le, FAN Jian-jun, et al.
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Second Department of Orthopaedics, the First Hospital Affiliated to Baotou Medical College, Neimenggu 014010, China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical significances of IL-18 and TNF-α in the development of osteoarthritis.Methods Seventy-one patients with knee osteoarthritis were selected as OA group and 30 healthy adults as control group. Radioimmunoassay was used to check the contents of IL-18 and TNF-α in articular synovial fluid, and the results were analyzed statistically.Results The contents of IL-18 and TNF-α in articular synovial fluid in OA group were higher than those in control group(P<0.01).Conclusion IL-18 and TNF-α are involved in the pathological process of destruction of articular cartilage and synovial inflammation. |
| Key words: IL-18 TNF-α Synovial fluid Knee osteoarthritis |
