| 摘要: |
| ［摘要］ 目的 探讨多发性骨髓瘤(multiple myeloma,MM)患者治疗前后血浆左旋肉碱含量及临床意义。方法 选取10名正常人及36例MM患者（初诊21例，复发15例）。所有患者均接受含或不含蒽环类的方案化疗，采用高效液相色谱法检测患者及正常人的血浆左旋肉碱水平。结果 无论初诊或复发患者的血浆左旋肉碱水平均低于正常人,化疗前复发患者组血浆左旋肉碱水平低于初治患者组，差异均具有统计学意义(P<0.05）；化疗后1 d及1周患者的血浆左旋肉碱水平均低于治疗前，含有蒽环类药物的方案可明显降低血浆左旋肉碱的水平，差异有统计学意义(P<0.05）。结论 化疗可导致MM患者的血浆左旋肉碱水平低下，化疗过程中补充左旋肉碱具有重要的意义。 |
| 关键词: 多发性骨髓瘤 左旋肉碱 |
| DOI：10.3969/j.issn.1674-3806.2015.05.07 |
| 分类号:R 733.3 |
| 基金项目:广西卫计委科研课题（编号：Z2011431） |
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| The changes of plasma L-carnitine levels in patients with multiple myeloma and their clinical significances |
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XU Li, MA Na, LI Yong-gan, et al.
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Departmen of Hematology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the changes of plasma L-carnitine levels in the patients with multiple myeloma(MM) before and after the chemotherapy and explore their clinical significances.Methods The levels of plasma L-carnitine of 10 healthy people and 36 MM patients(21 initially-diagnosed and 15 relapsed patients with MM) were tested. All patients were given chemotherapy with or without anthracyclines and the levels of plasma L-carnitine were tested by high performance liquid chromatography.Results The levels of plasma L-carnitine of initially-diagnosed and relapse patients with MM were lower than those of healthy people, but the levels of relapsed MM were lower than those initially-diagnosed MM(P<0.05）; Those levels of plasma L-carnitine of MM one day and one week after chemotherapy were lower than those before chemotherapy. Chemotherapy with anthracyclines can reduce the levels of plasma L-carnitine of MM patients (P<0.05）.Conclusion Chemotherapy could ruduce the levels of plasma L-carnitine of MM patients,indicating that it could be important to supplement L-carnitine during the chemotherapy. |
| Key words: Multiple myeloma（MM） L-carnitine |
