| 摘要: |
| ［摘要］ 目的 观察氨氯地平阿托伐他汀钙片治疗高血压合并冠心病患者的临床效果与安全性。方法 随机选取2012-07～2014-07收治的100例高血压合并冠心病患者作为研究对象，按照随机数字表法将其分为观察组与对照组各50例。观察组给予氨氯地平阿托伐他汀钙片治疗，对照组给予硝苯地平控释片治疗，比较两组患者血压、血脂、临床疗效及不良反应发生情况。结果 观察组显效34例，有效13例，无效3例。对照组显效13例，有效22例，无效15例，观察组临床疗效优于对照组（P<0.01）。治疗后，观察组收缩压、舒张压、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）均低于对照组（P<0.05），高密度脂蛋白胆固醇（HDL-C）高于对照组（P<0.05）。观察组总不良反应发生率为4.0%，明显低于对照组的26.0%（P<0.05）。结论 采用氨氯地平阿托伐他汀钙片治疗高血压合并冠心病，可有效控制血压，改善患者的血脂水平，药物安全性较高，患者不良反应发生率较低，且疗效显著，值得推广。 |
| 关键词: 高血压 冠心病 氨氯地平阿托伐他汀钙片 疗效 安全性 |
| DOI：10.3969/j.issn.1674-3806.2015.07.15 |
| 分类号:R 544.1；R 541.4 |
| 基金项目: |
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| The therapeutic effect and safety of amlodipine and atorvastatin calcium tablets on hypertension with coronary heart disease |
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CHEN Wei, CHEN Ci
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Department of Cardiovascular Internal Medicine, the People′s Hospital of Baoan District of Shenzhen City, Guangdong 518101, China
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| Abstract: |
| ［Abstract］ Objective To observe the clinical effect and safety of amlodipine and atorvastatin calcium tablets on the patients with hypertension and coronary heart disease.Methods 100 patients with hypertension and coronary heart disease were randomly selected in our hospital from July 2012 to July 2014 and randomly divided into the control group and the observation group, with 50 cases in each group. The control group received nifedipine treatment and the observation group was given amlodipine and atorvastatin calcium tablets. The incidence of blood pressure, blood lipid, clinical curative effect and adverse reaction were compared between the two groups.Results In the 50 cases of the observation group, 34 cases had markedly effective result, 13 cases had effective results and 3 cases had no effects. In the control group, 13 cases had markedly effective results, 22 cases had effctive results and 15 cases were invalid. Tsystolic blood pressure, diastolic blood pressure, TG and LDL-C were significantly lower in the observation group than those in the control group after the treatment(P<0.05). And HDL-C was higher in the observation group than that in the control group(P<0.05); The overall incidence of adverse reactions in the observation group was significantly lower than that in the control group(4.0% vs 26.0%)(P<0.05).Conclusion Amlodipine and atorvastatin calcium tablets is a safe and effective treatment in controling blood pressure and improving the blood lipid level on patients with hypertensive and coronary heart disease. |
| Key words: Hypertension Coronary heart disease Amlodipine and atorvastatin calcium tablets Efficacy Safety |
