| 摘要: |
| ［摘要］ 目的 探讨术后涂抹雌激素类药物对腹腔镜下腹膜阴道成形术患者人工阴道微生态的影响。方法 将80例先天性无阴道患者均分为观察组和手术对照组，均行腹腔镜下腹膜阴道成形术，观察组在此基础上应用苯甲酸雌二醇软膏。分别于取出阴道填纱当日、第1周、第2周、第3周及出院后3个月、6个月（分别标记为T0～T5）取人工阴道侧壁分泌物，行阴道微生态检测。另以40例健康体检对象为健康对照组，分别于体检当日、第1周、第2周、第3周和随后的第3个月、6个月检测上述项目。结果 T0～T1观察组人工阴道pH与手术对照组接近，且均明显高于健康对照组（P<0.05）；T2～T4观察组pH明显低于手术对照组（P<0.05），但较健康对照组仍明显更高（P<0.05）；T5观察组已接近于对照组；T0～T3观察组人工阴道微生态正常率与手术对照组接近，明显低于健康对照组（P<0.05）；T4～T5观察组上述指标基本正常；手术对照组T0～T3、观察组T0～T1阴道优势菌为棒状杆菌，两组其它时点及健康对照组阴道优势菌为乳酸杆菌。结论 应用雌激素类药物有助于改善腹膜阴道成形术后人工阴道微生态，值得推广。 |
| 关键词: 腹腔镜 腹膜 阴道成形术 苯甲酸雌二醇 微生态 |
| DOI：10.3969/j.issn.1674-3806.2015.08.05 |
| 分类号:R 713.3+1 |
| 基金项目:罗湖区软科学研究计划项目（编号：2012-56） |
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| Effects of smearing hormonal drugs on artificial vaginal epithelium after laparoscopic peritoneal vaginoplasty |
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YU Hong-biao, QIN Cheng-lu, LUO Guang-nan, et al.
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Department of Gynecology, the People′s Hospital of Luohu District of Shenzhen City, Guangdong 518001, China
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| Abstract: |
| ［Abstract］ Objective To investigate the postoperative effects on the micro-ecology of artificial vagina after smearing hormonal drugs on the patients undergoing the laparoscopic peritoneal vaginoplasty.Methods 80 patients with congenital absence of the vagina were selected and divided into the observation group and the control group. All patients underwent laparoscopic peritoneal vaginoplasty. The patients in the observation group were treated with estradiol benzoate based on the above treatment. The secretions on the artificial vaginal wall were extracted and the micro-ecology of vagina was detected when the filling yarn in the vagina was taken out on the first day, the first week, the second week, the third week and the three and six months(labeled T0～T5) after discharge. Other 40 healthy examined people were selected as the control group who were performed the same detection on the first examination day and at the end of the first week, the second week, the third week, the third month and the sixth month.Results The artificial vagina pH in the observation group during the period of T0～T1 was close to that in the operation control group but higher than that in the control group(P<0.05). The artificial vagina pH in the observation group during the period of T2～T4 was significantly lower than that in the operation control group(P<0.05), but was significantly higher than that in the control group(P<0.05). The artificial vagina pH in the observation group during the period of T5 was close to that in the control group. The normal rate of micro-ecology of the artificial vagina in the observation group during the period of T0～T3 was close to that in the operation control group but significantly lower than that in the control group(P<0.05). The indexes above in the observation group during the period of T4～T5 were basically normal. The vaginal dominant bacteria in the control group during the period of T0～T3 and in the observation group during the period of T0～T1 were gram positive small coli. The vaginal dominant bacteria in the two groups during other time slots and in the control group were gram positive bacteria.Conclusion Application of hormonal drugs can improve the micro-ecology of artificial vagina after the peritoneal vaginoplasty. |
| Key words: Laparoscope Peritoneal Vaginoplasty Estradiol benzoate Microecology |
