| 摘要: |
| ［摘要］ 目的 探讨硫辛酸联合普瑞巴林治疗痛性糖尿病神经病变的临床疗效。方法 将84例痛性糖尿病神经病变患者随机分为对照组和观察组各42例，对照组给予硫辛酸治疗，观察组给予硫辛酸联合普瑞巴林治疗，均治疗4周，观察两组患者治疗前后疼痛程度、神经传导速度变化及不良反应发生情况。结果 观察组患者治疗后疼痛视觉模拟评分(VAS)降低幅度明显优于对照组（P<0.01）。两组患者治疗后神经传导速度均较前增快，组间比较差异无统计学意义（P>0.05）。观察组显效5例，有效35例，无效2例。对照组显效3例，有效31例，无效8例。观察组疗效优于对照组（Z=1.88,P<0.05），但两组不良反应发生率比较差异无统计学意义（P>0.05），均无严重不良反应发生。结论 硫辛酸联合普瑞巴林治疗痛性糖尿病神经病变能更好地缓解疼痛，提高治疗效果，临床应用安全有效。 |
| 关键词: 痛性糖尿病神经病变 硫辛酸 普瑞巴林 疗效 |
| DOI：10.3969/j.issn.1674-3806.2015.08.10 |
| 分类号:R 587.2 |
| 基金项目: |
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| Clinical effect of thioctic acid combined with pregabalin on painful diabetic neuropathy |
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GENG Xiang-hua
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Department of Endocrinology, the Gulou Hospital of Kaifeng, Henan 475000, China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical effect of thioctic acid combined with pregabalin on painful diabetic neuropathy.Methods 84 patients with painful diabetic neuropathy were randomly divided into the control group and the observation group, with 42 cases in each group. The control group was treated with thioctic acid and the observation group was treated with thioctic acid combined with pregabalin. All of the courses of the treatment were 4 weeks. The patients′ pain degree, nerve conduction velocity and occurrence of adverse reactions were observed before and after the treatment.Results The reduction of VAS score in the observation group was obviously better than that in the control group（P<0.01). The nerve conduction velocity was faster in both of the two groups after the treatment than that before the treatment. There was no significant difference between the two groups（P>0.05）. In the observation group, the clinical effect was excellent in 5 cases, good in 35 cases and invalid in 2 cases. In the control group, the clinical effect was excellent in 3 cases, good in 31 cases and invalid in 8 cases. The curative effect of the observation group was better than that of the control group(t=1.88,P<0.05). The occurrence rate of adverse reactions is not significantly different between the two groups（P>0.05）. No serious adverse reactions occurred in the two groups.Conclusion The thioctic acid combined with pregabalin in the treatment of the painful diabetic neuropathy is safe and effective to relieve pain and improve therapeutic effect. |
| Key words: Painful diabetic neuropathy Thioctic acid Pregabalin Curative effect |
