| 摘要: |
| ［摘要］ 目的 观察分析盐酸氟桂利嗪治疗脑动脉硬化症患者的临床疗效和安全性。方法 选取100例脑动脉硬化症患者，随机分为观察组和对照组各50例。两组均给予控制血糖、血压，调整血脂药物，抗血小板和应用血塞通治疗。在此基础上，观察组给予盐酸氟桂利嗪10 mg，每晚睡前服用1次，治疗2周后，观察比较两组的临床疗效及安全性。结果 观察组显效27例，有效16例，无效7例；对照组显效13例，有效19例，无效18例。观察组临床疗效优于对照组（P<0.01）。两组患者全血高切粘度、血浆粘度及全血低切粘度均较治疗前降低(P<0.05或P<0.01)，观察组降低幅度明显大于对照组(P<0.01)，均未发生严重不良反应。结论 在脑动脉硬化症常规治疗基础上加用盐酸氟桂利嗪可收到显著的疗效，并能兼顾心血管疾病、癫痫及周围血管病的治疗，能明显提高安全性。 |
| 关键词: 盐酸氟桂利嗪 脑动脉硬化症 疗效 不良反应 |
| DOI：10.3969/j.issn.1674-3806.2015.09.12 |
| 分类号:R 743.1 |
| 基金项目: |
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| Analysis of the efficacy and safety of flunarizine hydrochloride in the treatment of cerebral arteriosclerosis |
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LI Gui-ying
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Department of Neurology, the Ninth People′s Hospital of Zhengzhou City, Henan 450053, China
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| Abstract: |
| ［Abstract］ Objective To analyse the clinical efficacy and safety of flunarizine hydrochloride in the treatment of cerebral arteriosclerosis.Methods 100 patients with cerebral arteriosclerosis were randomly divided into the observation group and the control group, with 50 cases in each group. The two groups were given the control of blood glucose, blood pressure, adjusting blood lipid, and anti- platelet by Xuesaitong treatment. Besides the above treatments, the observation group was given flunarizine hydrochloride 10 mg, one time per 24 hours. After two weeks of the treatment, the clinical efficacy and safety were compared between the two groups.Results The efficacy of the observation group was markedly effective in 27 cases, effective in 16 cases and invalid in 7 cases; the efficacy counterparts of the control group were 13, 19, 18 respectively. The total efficacy of the observation group was better than that of the control group(P<0.01). Whole blood viscosity, plasma viscosity and whole blood low shear viscosity in the two groups were lower than those before treatment(P<0.01), the above indicators of the observation group decreased more significantly than those of the control group(P<0.01). No serious adverse reactions occurred in the two groups.Conclusion Flunarizine hydrochloride is safe and effective in the treatment of cerebral arteriosclerosis. |
| Key words: Flunarizine hydrochloride Cerebral arteriosclerosis Efficacy Adverse reaction |
