| 摘要: |
| ［摘要］ 骨质疏松症是以骨强度下降、骨折风险增加为特征的骨骼系统疾病。骨强度反映了骨骼的骨密度和骨质量的特性。而骨质疏松症的严重后果是骨质疏松性骨折(即脆性骨折)，这是由于骨强度的下降，在受到轻微创伤时即可发生骨折，这大大增加了老年人的病残率和病死率。而骨密度是目前诊断骨质疏松症、预测脆性骨折风险、监测自然病程以及评价药物干预疗效的最佳指标。骨折发生的危险度与低骨密度有关，若同时伴有其他危险因素则会增加骨折的危险性。维生索D受体基因被认为是调控骨量的候选基因之一，但维生素D受体基因多态性与骨质疏松症的关系在不同人群中的研究仍存在较大的争议，该文就维生素D受体基因Fok I、Bsm I、Apa I、Taq I多态性与骨质疏松症的关系作一综述。 |
| 关键词: 骨质疏松症 维生素D受体基因 多态性 |
| DOI：10.3969/j.issn.1674-3806.2015.09.32 |
| 分类号:R 68 |
| 基金项目: |
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| Advances in the study of vitamin D receptor gene Fok I, Bsm I, Apa I, Taq I polymorphism and osteoporosis |
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LI Fu-lin, HUANG Yu, YIN Dong
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Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Osteoporosis(OP) is a complex multifactorial disease which is decreasing in bone strength and increasing the risk of facture. Bone strength includes two sides of skeleton, which are bone mineral density（BMD） and bone quality. As the serious OP consequences, skeleton may be fractured when it is hit by the trauma, which increases the rate of the elderly invalidism and fatality. BMD is the most excellent index, which may be used for diagnosing and predicting brittle fracture, detecting natural progression and drug intervention evaluation. The facture is related to low BMD and it may increase the risk of frature if other risk factors exists.Vitamin D receptor（VDR） gene is considered one of candidate genes in the bone mass regulation. The relationship of OP and VDR gene polymorphism has various viewpionts in the researches of different population. We review the relationship between VDR gene polymorphism and OP in this paper. |
| Key words: Osteoporosis(OP) Vitamin D receptor gene Polymorphism |
