| 摘要: |
| ［摘要］ 目的 研究虎杖降脂颗粒对饮食性大鼠高脂血症的治疗作用。方法 采用高脂性饮食诱导大鼠高脂血症，给予口服不同剂量的虎杖降脂颗粒，观察药物对模型动物血脂水平、体质量变化和肝脏脏器指数，肝脏脂质TC、TG，血清AST、ALT、肌酐和尿素氮以及肝脏组织形态的影响。结果 虎杖降脂颗粒各剂量组大鼠肝指数及肝组织脂质TC和TG均明显下降（P<0.05或P<0.01）；血清中TC、LDL-C、HDL-C含量不同程度地降低（P<0.05或P<0.01），但对TG作用不明显；血清AST、ALT有不同程度的降低（P<0.05或P<0.01），但对血清肌酐和尿素氮无明显作用。肝组织病理学结果表明，虎杖降脂颗粒各剂量组能不同程度地降低模型大鼠的肝脏脂肪变性程度。结论 虎杖降脂颗粒可有效调节高脂乳剂所致高脂血症大鼠血脂和肝脂水平，对高脂血症具有较好的调脂作用。 |
| 关键词: 虎杖降脂颗粒 血脂 肝脏脂质 高脂血症 |
| DOI：10.3969/j.issn.1674-3806.2015.10.02 |
| 分类号:R 589.2 |
| 基金项目:南宁市科学研究与技术开发计划项目（编号：201109056C)；广西研究生教育创新计划项目(编号：YCSZ2014117) |
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| The effects of Huzhangjiangzhi granules on hyperlipidemia in rats |
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GUO Mei-hong, HUANG Xiao-dan, FAN Ying, et al.
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School of Pharmacy, Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To study the therapeutic effects of HuzhangJiangzhi Granules on hyperlipidemia in diet-induced rats.Methods The hyperlipidemia rat model was induced by administrating with high fat emulsion and different doses of HuzhangJiangzhi Granules were given orally to rats. The effects of the drug on the levels of lipids, AST, ALT, creatinine, urea nitrogen in serum, the levels of TC, TG in liver, the liver index and morphologic changes of liver were observed.Results HuzhangJiangzhi Granules in different doses reduced significantly the levels of liver index, liver TC and TG, serum TC, LDL-C and HDL-C, serum AST and ALT（P<0.05 or P<0.01）, but had no effects on serum TG levels, serum creatinine and urea nitrogen. The results of liver histopathology indicated that HuzhangJiangzhi Granules reduced significantly liver steatosis.Conclusion HuzhangJiangzhi Granules can regulate hyperlipidemia in rats. |
| Key words: Huzhangjiangzhi granules Serum lipid Liver lipid Hyperlipidemia |
