| 摘要: |
| ［摘要］ 目的 探讨老年肾病综合征的临床表现和病理特点。方法 收集60岁以上老年肾病综合征患者41例，对其临床表现及肾活检病理进行分析。结果 41例患者中，原发性肾小球疾病28例（68.29%），病理类型以膜性肾病最常见，其次为局灶节段性肾小球硬化、微小病变性肾病；继发性肾病综合征13例（31.71%）。除肾病综合征表现外，伴血尿25例（60.98%），高血压24例（58.54%），肾功能异常20例（48.78%）。病程中出现感染11例（26.83%）。肾活检后无严重并发症。结论 老年肾病综合征最常见的病因为原发性肾小球疾病，病理类型以膜性肾病最常见。主要临床表现为浮肿、血尿、高血压、肾功能减退，并发症主要为感染。行肾活检对老年患者是安全的。 |
| 关键词: 肾病综合征 临床表现 病理类型 老年 |
| DOI：10.3969/j.issn.1674-3806.2015.10.14 |
| 分类号:R 692 |
| 基金项目: |
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| Nephrotic syndrome in the elderly: clinical and pathological analyses |
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LIU Xiao-cong, SHAO Si-nan, ZHANG Yan-lin
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Department of Nephrology, the First Affiliated Hospital of Xiamen University, Fujian 361003, China
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| Abstract: |
| ［Abstract］ Objective To analyze the clinical manifestations and pathologic characters of nephrotic syndrome in elderly patients.Methods We collected 41 nephrotic syndrome patients who were more than 60 years old in our hospital from January 2009 to January 2014 and analyzed their clinical manifestations and pathologic characters.Results All of the 41 cases with nephrotic syndrome were diagnosed by renal biopsy, with 28 cases in primary glomerular disease(68.29%), in which membranous nephropathy was the most common pathological type, followed by focal segmental glomerular sclerosis and minimal change disease, and with 13 cases in secondary nephrotic syndrome(31.71%). Except for nephrotic syndrome, hematuria was found in 25 cases(60.98%), hypertension in 24 cases(58.54%), renal dysfunction in 20 cases(48.78%). Infection was the major complication(26.83%). No serious complications were found after the renal biopsy.Conclusion The most common disease in the elderly patients with nephrotic syndrome is primary glomerular disease, in which membranous nephropathy is the most common pathological type. Major clinical manifestations are edema, hematuria, high blood pressure and high incidence of renal function impairment. Infection is the major complication. Renal biopsy is safe to apply in the elderly patients with nephrotic syndrome. |
| Key words: Nephrotic syndrome Clinical manifestation Pathology Elderly |
