| 摘要: |
| ［摘要］ 目的 观察二甲双胍联合达英-35治疗多囊卵巢综合征的疗效及对排卵率和妊娠率的影响。方法 对该院接收的68例多囊卵巢综合征患者随机分为A组和B组，每组34例。A组给予二甲双胍联合达英-35治疗，停药后服用克罗米芬，B组仅服用克罗米芬治疗，两组均治疗80个周期。对比分析两组的临床疗效及排卵率与妊娠率。结果 A组患者经过治疗后，痤疮、闭经、月经稀发明显改善(P<0.05)，而治疗前后多毛改善均不明显(P>0.05)，生殖内分泌激素［促卵泡激素(FSH）、促黄体激素（LH）、雌二醇（E2）、睾酮（T)］与治疗前相比均下降（P<0.05）。B组治疗结果类似。两组相比差异无统计学意义(P>0.05)。A组的排卵率为72.50%，妊娠率为32.35%，均显著高于B组（分别为53.75%、8.82%），P<0.05。结论 多囊卵巢综合征患者采用二甲双胍联合达英-35治疗，能有效改善月经不规律、痤疮以及高雄激素体征等症状，调整体内生殖内分泌激素水平，显著提高患者的排卵率与妊娠率。 |
| 关键词: 多囊卵巢综合征 达英-35 二甲双胍 妊娠 排卵 |
| DOI：10.3969/j.issn.1674-3806.2015.10.17 |
| 分类号:R 711.75 |
| 基金项目: |
|
| The curative effect of metformin in combination with dyne-35 on the treatment of polycystic ovary syndrome and on the ovulation rate and pregnancy rate |
|
HAN Yu-feng
|
|
Department of Obstetrics and Gynecology, Yuzhou Traditional Chinese Medicine Hospital, Henan 461670, China
|
| Abstract: |
| ［Abstract］ Objective To observe the curative effect of metformin in combination with dyne-35 on the treatment of polycystic ovary syndrome and on the ovulation rate and pregnancy rate.Methods Sixty-eight patients with polycystic ovary syndrome in our hospital were randomly divided into group A and group B, with 34 cases in each group. Group A was given metformin combined with dyne-35 and then G′Finn after withdrawing the above medication. Group B was given G′Finn treatment alone. Both of the two groups were treated with 80 circles. The ovulation rate and the pregnancy rate were compared between the two groups.Results Acne, amenorrhea and menstrual thin hair improved significantly in group A after the treatment(P<0.05), while hairy improvement was not obvious after the treatment(P>0.05). Reproductive endocrine hormones(FSH, LH, E2, T) of group A decreased obviously compared with those before the treatment(P<0.05). The similar results occurred in group B. There was no significant difference between group A and group B(P>0.05). The ovulation rate(72.50%) and pregnancy rate(32.35%) of group A were significantly higher than those of group B（53.75%, 8.82%）(P<0.05).Conclusion In patients with polycystic ovary syndrome, using metformin combined with dyne-35 treatment can effectively improve irregular menstruation, acne, and symptoms such as high androgen signs, adjust the reproductive endocrine hormone level inside body, significantly increase the ovulation rate and pregnancy rate. |
| Key words: Polycystic ovary syndrome(PCOS) Dyne-35 Metformin Pregnancy Ovulation |
