| 摘要: |
| ［摘要］ 目的 探讨大鼠肝纤维化中大黄蛰虫胶囊对基质金属蛋白酶-2（MMP-2）活性的影响。方法 采用明胶酶谱法检测肝组织MMP-2活性，采用天狼猩红染色法判断肝纤维化程度。结果 随着肝纤维化程度的加重，大黄蛰虫胶囊组MMP-2活性升高幅度明显低于模型组（P<0.05），但高于空白组（P<0.05）。结论 大黄蛰虫胶囊可能通过降低MMP-2活性抑制大鼠肝纤维化发展。 |
| 关键词: 大黄蛰虫胶囊 肝纤维化 基质金属蛋白酶-2 大鼠 明胶酶谱 |
| DOI：10.3969/j.issn.1674-3806.2015.11.09 |
| 分类号:Q 95-3;R 657.31;R 285.5 |
| 基金项目: |
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| The effect of Dahuangzhechong capsule on matrix metalloproteinase-2 activity in rats with hepatic fibrosis |
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GUO Shan-shan, FAN Xiu-fang, WANG He-xiang, et al.
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Department of Pathology, Hiser Hospital, Shandong 266000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the effect of Dahuangzhechong capsule on matrix metalloproteinase-2(MMP-2) activity in rats with hepatic fibrosis.Methods The collagen deposition and MMP-2 activity in the liver tissues were detected by Sirius red staining and zymography respectively.Results With the severity of liver fibrosis, the rising of MMP-2 activity in Dahuangzhechong capsule group was significantly lower than that in the liver fibrosis model group(P<0.05), but greater than that in the control group(P<0.05).Conclusion Dahuangzhechong capsule has a depressant effect on MMP-2 activity and inhibits the development of hepatic fibrosis in rats. |
| Key words: Dahuangzhechong capsule Hepatic fibrosis Matrix metalloproteinase-2(MMP-2) Rat Zymography |
