| 摘要: |
| ［摘要］ 目的 探讨血脑源性神经营养因子（BDNF）、同型半胱氨酸（Hcy）和生长抑素（SS）联合监测在脑卒中后血管性痴呆（VD）中的诊断价值。方法 选取30例脑卒中后血管性痴呆患者为VD组、30例脑卒中（非血管性痴呆）患者为脑卒中组和30名健康体检者为对照组。分析VD组、脑卒中组的危险因素及相关病史，比较三组间血BDNF、Hcy和SS水平差异，不同严重程度VD患者血BDNF、Hcy和SS水平差异。结果 （1）VD组、脑卒中组高血压病史比较，差异有统计学意义（P<0.05）；（2）VD组血BDNF、SS水平低于脑卒中组、对照组（P<0.01）；VD组血Hcy水平明显高于脑卒中组和对照组（P<0.01）；（3）不同严重程度VD患者血BDNF、Hcy和SS水平比较，差异有统计学意义（P<0.01）。结论 动态观察VD患者血BDNF、Hcy和SS水平，有利于血管性痴呆的早期诊断和评估病情严重程度。 |
| 关键词: 血管性痴呆 脑卒中 联合监测 |
| DOI：10.3969/j.issn.1674-3806.2016.03.11 |
| 分类号:R 749.1+3 |
| 基金项目: |
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| Research of BDNF, Hcy and SS in the diagnosis of vascular dementia after stroke |
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LI Shao-hui, LI Mao-qing, ZHONG Jun-jie
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Department of Rehabilitation Medicine, the First People′s Hospital of Huizhou City, Guangdong 516003, China
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| Abstract: |
| ［Abstract］ Objective To investigate the value of cerebral blood source of nerve neurotrophic factor(BDNF), homocysteine(Hcy) and somatostatin(SS) combined with monitoring in the diagnosis post-stroke vascular dementia(VD).Methods Thirty patients with VD after stroke were selected as VD group, 30 patients with cerebral apoplexy(non vascular dementia) as stroke group and 30 healthy people as the control group. The risk factors and related history of the VD group and the stroke group were analyzed, and the differences of Hcy, SS and BDNF were compared among the three groups and the levels of SS, Hcy and BDNF were compared among the three subgroups of the VD group with different levels of severity of VD.Results (1)There was significant difference in the history of hypertension between the VD group and the stroke group(P<0.05);(2)The levels of serum BDNF and SS in the VD group were lower than those in the stroke group and the control group(P<0.01); serum level of Hcy in the VD group was significantly higher than that in the stroke group and the control group(P<0.01);(3)The levels of serum BDNF, Hcy and SS among different levels of severity in VD patients were significant different(P<0.01).Conclusion The levels of serum SS, Hcy and BDNF are beneficial to the early diagnosis and assessment of the severity of vascular dementia. |
| Key words: Vascular dementia Stroke Combined monitoring |
