| 摘要: |
| ［摘要］ 目的 对来宾市新生儿α-地中海贫血情况进行筛查，为来宾市α-地中海贫血的临床诊断及防治提供参考依据。方法 收集2014-05～2015-04该院住院分娩的2 050例新生儿脐带血标本，采用琼脂糖凝胶电泳测定HbBart′s含量，分析新生儿α-地中海贫血的发生情况。结果 2 050例新生儿中共检出α-地中海贫血272例，阳性率为13.27%，其中静止型137例（50.37%），标准型129例（47.43%），HbH 6例（2.20%）。结论 利用琼脂糖凝胶电泳能快速、有效筛查新生儿α-地中海贫血。来宾市为α-地中海贫血高发区，需积极开展α-地中海贫血防治工作，提高出生人口素质。 |
| 关键词: 新生儿 α-地中海贫血 脐带血 HbBart′s含量 琼脂糖凝胶电泳 |
| DOI：10.3969/j.issn.1674-3806.2016.03.18 |
| 分类号:R 556.6+1 |
| 基金项目: |
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| Analysis of screening for α-thalassemia in 2 050 neonates in Laibin city |
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SHI Ze-lian, WU Zhi-feng, QIN Hui-ni, et al.
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Department of Clinical Laboratory, the People′s Hospital of Wuxuan County, Guangxi 545900, China
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| Abstract: |
| ［Abstract］ Objective To screen for α-thalassemia in the neonates in Laibin city, and to provide the evidence for the clinical diagnosis, prevention and treatment of the disease.Methods Umbilical cord blood was collected from 2 050 neonates in our hospital from May 2014 to April 2015. The HbBart′s contents of the neonates were determinated by the agarose gel electrophoresis. The incidence of neonates with α-thalassemia was calculated.Results Two hundrend and seventy-two cases with α-thalassemia were checked out from 2 050 neonates. The positive rate was 13.27%, of which 137 cases(accounting for 50.37%) with static type,129 cases(accounting for 47.43%) with standard type, and 6 cases(accounting for 2.21%) with Hemoglobin H disease.Conclusion The agarose gel electrophoresis is an efficient method fror quickly screening out α-thalassemis in neonates. Laibin city is an area with a high incidence of α-thalassemia. Active prevention and controlling measures should improve the population quality in this area. |
| Key words: Neonate α-thalassemia Umbilical cord blood HbBart′s content Agarose gel electrophoresis |
