| 摘要: |
| ［摘要］ 男性生育力受到许多因素的影响，其中精子DNA损伤一直是生殖医学领域研究的热点之一。该损伤可由多种因素诱发精子DNA双链断裂或使其双链变性而形成。该文通过分析精子生成错误、氧化应激、精子染色质包装异常、疾病等因素对精子DNA损伤的影响，阐述精子DNA损伤检测在辅助生殖医学中的研究现状，为进一步阐明精子DNA损伤的发生机制以及如何为辅助生殖技术选用高质量精子提供基础材料。 |
| 关键词: 精子DNA完整性 精子DNA损伤 精子染色质扩散试验 |
| DOI：10.3969/j.issn.1674-3806.2016.03.26 |
| 分类号:R 698+.2 |
| 基金项目:广西卫计委科研课题（编号：Z2014225） |
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| Research progress on sperm DNA damage of assisted reproductive technology |
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HUANG Yue-yue, XUE Lin-tao, HE Bing
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Reproductive Medicine and Genetics Center, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ The male fertility is affected by many factors, and sperm DNA damage is one of the research hotspots in assisted reproductive technology(ART). A number of factors can lead to the DNA strand breaks or make double-stranded DNA into single-stranded DNA. In this paper we review the damage factors of sperm DNA, including sperm production error, oxidative stress, abnormal assembling of chromatin, and the related diseases, which provides some basic information for elucidating the mechanism of DNA damage, and optimal spermatozoa selection in ART. |
| Key words: Sperm DNA integrity Sperm DNA damage Sperm chromatin dispersion test |
