| 摘要: |
| ［摘要］ 目的 研究转化生长因子-β1（TGF-β1）在乳腺纤维腺瘤组织以及其周围正常组织中的表达状况，探讨其在乳腺纤维腺瘤发病中的作用。方法 标本来源为该科接受肿物切除术后病理诊断为乳腺纤维腺瘤的组织标本。收集新鲜组织标本20例（每例含肿瘤组织以及周围正常组织）液氮保存，采用逆转录定量聚合酶链反应（RT-qPCR）检测TGF-β1 mRNA表达水平。所获实验数据以Student′s t检验进行统计分析。结果 RT-qPCR结果显示乳腺纤维腺瘤组织中TGF-β1 mRNA的表达水平高于瘤旁正常组织（P=0.004）。结论 乳腺纤维腺瘤组织中TGF-β1 mRNA的表达水平高于瘤旁组织，显示TGF-β1作为重要的间质发育的因子，也参与了纤维腺瘤的形成过程，其确切的作用过程仍待进一步的研究。 |
| 关键词: 乳腺 纤维腺瘤 转化生长因子-β1 |
| DOI：10.3969/j.issn.1674-3806.2016.05.05 |
| 分类号:R 737.9 |
| 基金项目:厦门市科技计划社会发展项目（编号：3502Z20114025） |
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| The expression of TGF-β1 and its clinical singnificances in female breast fibroadenoma |
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GUO Ju-jiang, LIAO Hong-ye, WENG Yi-yin, et al.
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Department of Breast Surgery, the Maternal and Child Health Care Hospital of Xiamen, Fujian 361003, China
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| Abstract: |
| ［Abstract］ Objective To study the expression of transforming growth factor - beta 1(TGF-β1) and it clinical singnificances in female breast fibroadenoma.Methods Twenty pairs of fresh tissue specimens including the tumor tissue and the matched normal tissue were collected from the female patients with breast fibroadenoma and were preserved in liquid nitrogen. The reverse transcription quantitative polymerase chain reaction(RT-qPCR) was used to detect the levels of TGF-β1 mRNA l in the samples. Student′s t-test was used to analyze the data.Results The expression of TGF-β1 mRNA was significantly elevated in the breast fibroadenoma tissues than that in the normal tissues(P=0.004).Conclusion As an important factor for the development of stroma, TGF-β1 is involved in the formation process of fibroadenoma. |
| Key words: Breast Fibroadenoma TGF-β1 |
