| 摘要: |
| ［摘要］ 目的 探讨基层医院急性ST段抬高型心肌梗死(STEMI)溶栓疗法中不同溶栓剂的选择和应用。方法 90例STEMI患者随机分为A组和B组各45例，A组采用瑞替普酶治疗，B组采用尿激酶溶栓治疗，比较两组的疗效及安全性。结果 与B组比较，A组血管再通率较高（88.9% vs 71.1%，P<0.05），特别是发病时间>6 h者（66.7% vs 12.5% P<0.05）；A组出院前左心室射血分数（LVEF）较高，脑钠肽（BNP）较低（P<0.05），心功能较好。两组均无致死性大出血及脑出血。结论 瑞替普酶能早期快速开通梗死相关血管，减少心肌损伤，改善心功能和预后，是STEMI患者的更佳选择。 |
| 关键词: 心肌梗死 瑞替普酶 尿激酶 溶栓 |
| DOI：10.3969/j.issn.1674-3806.2016.09.02 |
| 分类号:R 542.2+2 |
| 基金项目:福建省泉州市卫计委科研资助项目(编号:泉卫函［2013］391号) |
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| Comparison of the therapeutic effect between reteplase and urokinase on the treatment of patients with ST-segment elevation myocardial infarction |
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XIE Wen-tao, ZHANG Zhi-yang, YAN Wen-mei, et al.
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Department of Cardiology, the Hospital of Anxi County, Fujian 362400, China
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| Abstract: |
| ［Abstract］ Objective To summarize the thrombolytic therapy for the patients with acute ST-segment elevation myocardial infarction(STEMI) in a primary hospital.Methods Ninety patients with STEMI in our hospital from November 2013 to November 2015 were randomly divided into two groups:group A(n=45) and group B(n=45). Group A was treated with reteplase and group B received urokinase. The clinical effect and the incidence of adverse reactions were observed and compared between the two groups.Results Compared with group B, group A had a higher revascularization rate two hours(88.9% vs 71.1%, P<0.05), or six hours(66.7% vs 12.5%, P<0.05) after the thrombolytic therapy. Compared with group B, group A had a higher ejection fration, a lower BNP level and better cardiac function(P<0.05). There were no significant differences in the risk of bleeding and death between the two groups.Conclusion Reteplase can recanalize the infarct-ralated arteries, reduce myocardial injury, improve the heart function and prognosis in the patients with early STEMI. |
| Key words: Acute myocardial infarction Reteplase(r-PA) Urokinase(UK) Thrombolytic therapy |
