| 摘要: |
| ［摘要］ 目的 比较血管介入与单纯药物对粥样硬化性肾动脉狭窄（ARAS）患者控压水平及心功能的改善作用。方法 选择2012-01～2015-07收治的87例ARAS患者作为研究对象，根据患者意愿分为介入组45例和单纯药物组42例。比较两组治疗前后收缩压（SBP）、舒张压（DBP）、血清肌酐（Cr）、心功能分级、左室舒张末径（LVEDD）、左室射血分数（LVEF）及高血压治愈率、肾功能改善率。结果 两组治疗前SBP、DBP、Cr、心功能分级、LVEDD、LVEF比较差异无统计学意义(P均>0.05)，治疗后SBP、DBP均降低，治疗前后差异有统计学意义(P<0.05），但治疗后两组比较差异无统计学意义（P>0.05）；Cr治疗前后差异无统计学意义（P>0.05）。介入组治疗后心功能分级、LVEDD分别降低至(2.2±0.4）、(52.5±4.6)mm，低于治疗前及单纯药物组治疗后；LVEF升高至(53.3±4.1)%，高于治疗前及单纯药物组治疗后，差异均有统计学意义(P<0.05）。两组高血压治愈率与肾功能改善率无明显差异(P>0.05)。结论 与单纯药物治疗相比，介入治疗在血压控制与肾功能改善方面虽无明显优势，但心功能改善更佳，可减少心脑血管不良事件，进而发挥预防心血管并发症作用。 |
| 关键词: 粥样硬化性肾动脉狭窄 血管介入 单纯药物 心功能 血压 |
| DOI：10.3969/j.issn.1674-3806.2016.10.03 |
| 分类号:R 541 |
| 基金项目:肇庆市科技创新计划项目（编号：2014E211） |
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| Comparison between vascular interventional therapy and simple medication in blood pressure controlling and cardiac function in patients with atherosclerotic renal artery stenosis |
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TANG Liang-yu, WANG Shu-yuan, TAN Shao-ling, et al.
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Department of Cardiovascular Medicine, the First People′s Hospital of Zhaoqing, Guangdong 526000, China
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| Abstract: |
| ［Abstract］ Objective To compare the improving effects of vascular interventional therapy and simple medication in pressure-control level and cardiac function in the patients with atherosclerotic renal artery stenosis(ARAS).Methods Eight-seven patients with ARAS in our hospital between January 2012 and July 2015 were selected as the study subjects. According to the principle of voluntrary, they were divided into the intervention group(n=45) and the simple medication group(n=42). SBP, DBP, Cr, cardiac function grading, LVEDD, LVEF, the curative rate of hypertension and the improvement rate of renal function were compared between the two groups before and after the treatment.Results The differences in SBP, DBP, Cr, cardiac function grading, LVEDD and LVEF between the two group before the treatment were not significant(P>0.05). After the treatment, SBP and DBP in the two groups decreased and the differences before and after the treatment were significant(P<0.05). However, after the treatment, the differences between the two groups were not significant(P>0.05). Difference in Cr before and after the treatment was not significant(P>0.05). After the treatment, cardiac function grading and LVEDD in the intervention group were reduced to(2.2±0.4) and (52.5±4.6) mm, respectively which were significantly lower than those before the treatment and those in the simple medication group after the treatment; LVEF increased to (53.3±4.1)% which was higher than that before the treatment and that in the simple medication group after the treatment(P<0.05). The differences in the curative rate of hypertension and improvement rate of renal function between the two groups were not significant (P>0.05).Conclusion Compared with simple medication, interventional therapy has no obvious advantages in the control of blood pressure and the improvement of renal function, however it can improve cardiac function better and reduce adverse cardiovascular and cerebrovascular events and prevent cardiovascular complications. |
| Key words: Atherosclerotic renal artery stenosis Vascular interventional therapy Simple medication Cardiac function Blood pressure |
