| 摘要: |
| ［摘要］ 目的 观察醋酸去氨加压素联合奥昔布宁口服治疗儿童单症状性夜遗尿的临床疗效。方法 选取148例儿童单症状性夜遗尿患儿，随机分为观察组76例和对照组72例。两组均给予基础治疗并且口服常规剂量醋酸去氨加压素,观察组加用奥昔布宁。治疗3个月后观察疗效，停药后随访3个月观察复发情况。结果 观察组显效52例，有效19例，无效5例；对照组显效30例，有效26例，无效16例。观察组疗效优于对照组(P<0.01)。观察组停药后复发率为11.84%，低于对照组的25.00%,差异具有统计学意义(P<0.05)。结论 醋酸去氨加压素联合奥昔布宁治疗儿童单症状性夜遗尿比单独使用醋酸去氨加压素疗效更好，而且停药后复发率更低，值得在临床上推广应用。 |
| 关键词: 儿童单症状性夜遗尿 醋酸去氨加压素 奥昔布宁 |
| DOI：10.3969/j.issn.1674-3806.2016.11.06 |
| 分类号:R 725 |
| 基金项目:广东佛山市科技局医学类科技攻关项目（编号：2015AB002053） |
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| Curative effect of desmopressin acetate combined with oxybutynin in children with monosymptomatic nocturnal enuresis |
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ZHONG Qiong
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Department of Pediatrics, Shunde Leliu Hospital, Foshan 528322, China
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| Abstract: |
| ［Abstract］ Objective To observe the curative effect of desmopressin acetate combined with oxybutynin in the children with monosymptomatic nocturnal enuresis.Methods One hundred and forty-eight children with monosymptomatic nocturnal enuresis were randomly divided into the observation group（n=76） and the control group(n=72). The two groups were given the basic treatment and oral conventional dose of desmopressin acetate, and the observation group added with Oxybutynin. The curative effect was observed 3 months after the treatment. The patients were followed up for 3 months to observe the recurrence after the drug withdrawal.Results Fifty-two cases were markedly effective, 19 cases effective and 5 cases ineffective in the observation group while 30 cases were markedly effective, 26 cases effective and 16 cases ineffective in the control group. The curative effect of the observation group was significantly higher than that of the control group(93.4% vs 77.7%, P<0.01). After the drug withdrawal, the recurrence of the observation group was significantly lower than that of the control group(11.84% vs 25.00%, P<0.05).Conclusion Desmopressin acetate combined with oxybutynin is more effective than desmopressin acetate in the treatment of children with monosymptomatic nocturnal enuresis. |
| Key words: Monosymptomatic nocturnal enuresis in children Desmopressin acetate Oxybutynin |
