| 摘要: |
| ［摘要］ 目的 探讨他汀类药物对急性冠脉综合征（ACS）并肾功能不全患者脂代谢水平的影响。方法 选取2013-02～2014-07该院收治的96例ACS并肾功能不全患者，随机抽签分为常规组40例和他汀类药物组56例。常规组采用阿司匹林、β受体阻滞剂、硝酸酯类和血管紧张素转换酶抑制剂等常规药物治疗，他汀类药物组在常规治疗基础上采用他汀类药物治疗。他汀类药物组再分为小剂量组和大剂量组各28例，小剂量组采用小剂量他汀类药物治疗，大剂量组采用大剂量他汀类药物治疗，治疗3个月。观察常规组和他汀类药物组、小剂量组和大剂量组的总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）等血脂指标变化。结果 治疗前常规组和他汀类药物组血脂指标TC、TG、LDL-C、HDL-C比较差异无统计学意义（P>0.05）；治疗后他汀类药物组TC［（4.34±0.63）mmol/L］、TG［（1.56±0.52）mmol/L］、LDL-C［（2.43±0.62）mmol/L］分别较常规组［（5.21±0.75）mmol/L、（2.15±0.73）mmol/L、（2.91±0.81）mmol/L］明显降低，差异有统计学意义（P<0.05）。他汀类药物大剂量组TC［（4.04±0.65）mmol/L］、TG［（1.24±0.57）mmol/L］较小剂量组［（4.65±0.68）mmol/L、（1.75±0.74）mmol/L］显著降低，差异有统计学意义（P<0.05）。结论 他汀类药物能有效降低ACS并肾功能不全患者脂代谢水平，且大剂量他汀类药物降脂效果更佳。 |
| 关键词: 急性冠脉综合征 肾功能不全 他汀类药物 脂代谢 |
| DOI：10.3969/j.issn.1674-3806.2017.01.14 |
| 分类号:R 692 |
| 基金项目: |
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| Effect of statins on lipid metabolism levels in patients with acute coronary syndrome complicated with renal dysfunction |
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ZHOU Chun-juan
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Department of Internal Medicine-Cardiovascuilar, Wenxian County Second People′s Hospital, Henan 454850, China
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| Abstract: |
| ［Abstract］ Objective To study the effect of statins on lipid metabolism levels in patients with acute coronary syndrome(ACS) complicated with renal dysfunction.Methods Ninety-six patients with ACS complicated with renal dysfunction treated in our hospital from February 2013 to July 2014 were selected and randomly divided into 3 groups among whom 40 cases treated with routine drugs such as aspirin, β-blockers, nitrates and angiotensin converting enzyme inhibitors were taken as the routine group. The remaining 56 patients treated with statins based on the routine treatment were taken as the statins group; The statins group was subdivided into two groups, in which 28 patients were treated with low-dose statins were taken as the low-dose group while the other 28 cases were treated with high-dose statins(the high-dose group). The treatment lasted for 3 months. The changes of serum lipids indexes such as total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) were observed in the routine group, statins group, low-dose and high-dose group.Results After the treatment, TC, TG and LDL-C of the statins group were significantly lower than those of the routine group［（4.34±0.63） vs （5.21±0.75）mmol/L,（1.56±0.52） vs （2.15±0.73）mmol/L,（2.43±0.62） vs （2.91±0.81）mmol/L］(P<0.05); TC and TG of the high-dose group of the statins group were significantly lower than those of the low-dose group［（4.04±0.65） vs （4.65±0.68）mmol/L,（1.24±0.57） vs （1.75±0.74）mmol/L］(P<0.05).Conclusion Statins can effectively reduce the lipid level in patients with ACS and complicated with renal dysfunction and the effect of high-dose statins is better. |
| Key words: Acute coronary syndrome Renal dysfunction Statins Lipid metabolism |
