| 摘要: |
| ［摘要］ 目的 探讨2型糖尿病（T2DM）胰岛素抵抗与超敏C反应蛋白（hs-CRP）、血尿酸（SUA）和血脂代谢之间的关系。方法 收集T2DM患者共128例，测定患者空腹血糖（FPG）、餐后2 h血糖（2hPG）、空腹胰岛素（FIns）、SUA、hs-CRP及高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、甘油三酯（TG）等水平，按HOMA-IR水平的四分位间距进行分组，比较和分析组间各指标测定值。结果 各组间hs-CRP、SUA、TG、HDL-C水平比较差异有统计学意义（P<0.05），Pearson相关性分析显示HOMA-IR水平与hs-CRP、SUA、TG水平呈正相关，与HDL-C水平呈负相关（P<0.05）。多重线性回归分析显示hs-CRP、SUA、HDL-C进入方程，方程式为y=53.284+0.237X1+0.098X2-1.618X3。结论 hs-CRP、SUA、HDL-C与T2DM胰岛素抵抗严重程度密切相关。 |
| 关键词: 2型糖尿病 胰岛素抵抗 超敏C反应蛋白 血尿酸 血脂代谢 |
| DOI：10.3969/j.issn.1674-3806.2017.02.11 |
| 分类号:R 587.1 |
| 基金项目: |
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| Association of insulin resistance with high-sensitive C-reactive protein, serum uric acid and lipid metabolism in patients with type 2 diabetes mellitus |
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LIU Ling-xia
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Department of Endocrinology, the People′s Hospital of Chongzuo, Guangxi 532200, China
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| Abstract: |
| ［Abstract］ Objective To explore the relationship between insulin resistance and high-sensitive C-reactive protein, serum uric acid and lipid metabolism in the patients with type 2 diabetes mellitus(T2DM).Methods One hundred and forty-eight patients with T2DM were selected.The levels of fasting plasma glucose(FPG), 2-hour plasma glucose(2h PG), fasting insulin(Fins), serum uric acid(SUA), high-sensitive C-reactive protein(hs-CRP), high density lipoprotein cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C), total cholesterol(TC) and triglycerides(TG) were determined. The research subjects were divided into four groups according to the quartiles of HOMA-IR′s results. The results of all the items were compared among the four groups.Results The levels of hs-CRP, SUA, TG, HDL-C were significantly different among the four groups(P<0.05). The Pearson analysis showed that HOMA-IR was positively correlated with hs-CRP, SUA and TG, and was negatively correlated with HDL-C（P<0.05） The hs-CRP, SUA and HDL-L were entered the multiple linear regression analysis, and the equation was y=53.284+0.237X1+0.098X2-1.618X3.Conclusion There is a significant relationship between hs-CRP, SUA and HDL-L with IR in the patients with type 2 diabetes mellitus. |
| Key words: Type 2 diabetes mellitus Insulin resistance High-sensitive C-reactive protein Serum uric acid Lipid metabolism |
