| 摘要: |
| ［摘要］ 目的 分析胃间质瘤外科手术治疗及预后的相关性因素。方法 收集2008-06～2014-06于该院行手术治疗并经病理检查明确为胃间质瘤的62例患者的临床资料，统计并分析影响患者预后的因素。结果 所有患者均行手术治疗，平均随访时间为38.6（40.69±6.23）个月，随访率为96.77%。其1、3、5年总体生存率分别为91.45%、72.84%、60.47%。单因素分析显示，肿瘤细胞核分裂像、肿瘤大小、肿瘤坏死及NIH危险度分级是影响患者生存预后的因素。生存率与年龄、性别、生长类型等因素无明显相关差异。COX回归分析提示，核分裂像、NIH危险度分级是影响预后的独立因素， χ2分别为7.148和6.347（P<0.05）。相对危险度（RR）分别为3.276和4.266；95%CI>分别为1.437～7.476和1.271～10.622。结论 胃间质瘤的总体预后一般，肿瘤细胞核分裂像、肿瘤大小、肿瘤坏死及NIH危险度分级是影响胃间质瘤术后的预后因素，其中，核分裂像、NIH危险度分级是影响预后的独立因素。 |
| 关键词: 胃间质瘤 手术治疗 预后因素 |
| DOI：10.3969/j.issn.1674-3806.2017.07.18 |
| 分类号:R 735 |
| 基金项目: |
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| Analysis of factors related to surgical treatment and prognosis of gastric stromal tumors |
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LI Xing-hua
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The First Department of General Surgery, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Guangdong 514700, China
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| Abstract: |
| ［Abstract］ Objective To investigate the surgical treatment of gastric stromal tumors and the factors related to the prognosis.Methods Sixty-two patients with gastric stromal tumors were collected from June 2008 to June 2014 in our hospital. The clinical data and the prognostic factors were analyzed.Results All the patients underwent operation. The mean follow - up time was 38.6(40.69±6.23)months. The follow - up rate was 96.77%. The overall survival rates were 91.45%, 72.84% and 60.47% 1, 3 and 5 years after the operation respectively. The univariate analysis showed that tumor cell mitosis, tumor size, tumor necrosis and NIH risk grade were the prognostic factors. There were no significant correlations between the survival rate and age, gender, growth type and other factors. COX regression analysis showed that mitotic score and NIH risk grade were independent prognostic factors(χ2=7.148 and respectively 6.347）,(P<0.05). RRs were 3.276 and 4.266; 95%CI>s were 1.437～7.476 and 1.271～10.622, respectively.Conclusion The overall prognosis of the treatment of gastric stromal tumors is generally poor. Mitotic figures, tumor size, tumor necrosis and NIH risk grade are the prognostic factors that affect the postoperative staging of gastric stromal tumors. The mitotic score and NIH risk grade are prognostic factors of the independent factors. |
| Key words: Gastric stromal tumors(GSTs) Surgical treatment Prognostic factors |
