| 摘要: |
| ［摘要］ 目的 分层研究血清AFP水平与原发性肝癌(PHC)患者各临床症状和体征的相关性。方法 采用SPSS19.0软件统计分析PHC患者不同层次血清AFP水平中的各临床症状和体征。结果 本研究共纳入1 030例PHC患者，Logistic回归分析发现，年龄、腹痛、腹胀、影像学检查为块状型、病理检查为肝细胞型及胆管细胞型对血清AFP水平有明显影响。通过线性趋势分析发现肝硬化、腹痛、腹胀、腹水、肝大、影像学检查为块状型、大三阳及小三阳百分率随AFP水平的升高而呈现增加趋势，而影像学检查为结节型、病理检查为肝细胞型和胆管细胞型阳性百分率随AFP水平的升高而呈现下降趋势。结论 临床上应动态监测PHC患者血清AFP水平，并密切观察患者症状和体征的变化，更好地提高PHC患者的治疗效果。 |
| 关键词: 甲胎蛋白 原发性肝癌 症状 体征 |
| DOI：10.3969/j.issn.1674-3806.2018.02.07 |
| 分类号:R 543.5 |
| 基金项目:广西高校中青年教师基础能力提升项目（编号：2017KY0127） |
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| Relationship between symptoms, signs and serum levels of Alpha-fetoprotein in patients with primary hepatocellular carcinoma |
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ZHOU Xiao-ping, ZHANG Ling, WU Jun-rong
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Department of Laboratory Medicine, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530022, China
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| Abstract: |
| ［Abstract］ Objective To explore the relationship between symptoms, signs and different levels of Alpha-fetoprotein(AFP) in the patients with primary hepatocellular carcinoma(PHC).Methods SPSS19.0 was used to statistically analyze the symptoms and signs of PHC patients with different levels of AFP.Results A total of 1 030 PHC patients were included in this study. The results of the Logistic regression analysis showed that the following factors have a significant effect on AFP levels: age, abdominal pain, bloating, block type, type of liver cells and bile duct cell type. The results from the linear trend analysis indicated that the percentage of positive cirrhosis, abdominal pain, bloating, ascites, hepatomegaly, massive, HBsAg, HBeAg and Anti-HBc positive and HBsAg, Anti-HBe and Anti-HBc positive increased with elevated AFP, while the percentage of positive nodular, type of liver cells and bile duct cell type decreased with elevated AFP.Conclusion The serum levels of AFP should be dynamically detected and the clinical symptoms and signs should be observed carefully to make the PHC patients treated more timely and effectively. |
| Key words: Alpha-fetoprotein Primary hepatocellular carcinoma Symptom Sign |
