引用本文:韦 燕,卢小玲,原 浩,易海振,赵善琳.循环热灌注化疗联合替吉奥及热疗治疗老年胃癌癌性腹水的疗效观察[J].中国临床新医学,2018,11(9):873-876.
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循环热灌注化疗联合替吉奥及热疗治疗老年胃癌癌性腹水的疗效观察
韦 燕,卢小玲,原 浩,易海振,赵善琳
537100 贵港,广西医科大学第八附属医院(贵港市人民医院)肿瘤防治中心
摘要:
[摘要] 目的 观察循环热灌注化疗联合口服替吉奥化疗及内生场热疗治疗老年胃癌合并腹腔积液的临床疗效及其不良反应。方法 选择42例合并恶性腹腔积液老年胃癌患者,随机分为腹腔灌注联合替吉奥及热疗组(观察组)和替吉奥联合热疗组(对照组),两组均给予替吉奥口服化疗以及每3 d一次的内生场热疗,观察组另予以每3周一次的顺铂循环热灌注化疗。治疗2个疗程后评价疗效与不良反应。结果 观察组及对照组总原发肿瘤的有效率为57.1%及42.9%,腹水控制率分别为81.0%及47.6%,腹水肿瘤细胞转阴率分别为81.0%及38.1%。两组患者治疗过程中不良反应发生率明显差异,且均严重不良反应,未发生治疗相关性死亡。结论 循环热灌注化疗联合口服替吉奥全身化疗及内生场热疗治疗合并腹腔积液晚期胃癌疗效好,安全性高,可作为合并腹腔积液晚期胃癌可选的治疗方法。
关键词:  老年胃癌患者  循环热灌注治疗  内生场热疗  替吉奥  腹水
DOI:10.3969/j.issn.1674-3806.2018.09.07
分类号:R 735
基金项目:广西贵港市科学研究与技术开发计划项目(编号:贵科攻1504035)
Efficacy of circulatory thermo-chemotherapy combined with S-1 and endogenic field thermotherapy in treatment for elderly patients with ascites caused by advanced gastric carcinoma
WEI Yan, LU Xiao-ling, YUAN Hao, et al.
Cancer Center, the Eighth Affiliated Hospital of Guangxi Medical University(the People′s Hospital of Guigang City), Guigang 537100, China
Abstract:
[Abstract] Objective To evaluate the efficacy of circulatory thermo-chemotherapy combined with S-1 and endogenic field thermotherapy in treatment for elderly patients with ascites caused by advanced gastric carcinoma and the adverse reactions of the treatment. Methods 42 patients with gastric carcinoma were randomly divided into the observation group(receiving circulatory thermo-chemotherapy and cisplatin combined with S-1 and endogenic field thermotherapy) and the control group(receiving S-1 monotherapy combined with endogenic field thermotherapy). During the monotherapy of oral S-1, endogenic field thermotherapy(every three days as a cycle, 3 cycles totally) was given to the two groups, and the observation group was given additional circulatory thermo-chemotherapy(three weeks as a cycle, 3 cycles totally) with cisplatin. The curative effects and adverse reactions were evaluated after 2 cycles of treatment. Results The primary tumor efficiency rate was 57.1% in the observation group and 42.9% in the control group(P>0.05). The objective response rate of ascites was 81.0% in the observation group and 47.6% in the control group(P<0.05). The ascites negative conversion rate was 81.0% in the observation group and 38.1% in the control group. There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). No serious adverse reactions were found in the two groups after therapy and no treatment-related deaths occurred. Conclusion Circulatory thermo-chemotherapy and cisplatin combined with S-1 and endogenic field thermotherapy is safe and effective for the elderly patients with advanced gastric carcinoma with ascites.
Key words:  Elderly patients with gastric cancer  Circulatory thermo-chemotherapy  Endogenic field thermotherapy  S-1  Ascites