| 摘要: |
| ［摘要］ B细胞特异性莫罗尼鼠科白血病病毒集成位点1(B cell-specific Moloney murine leukemia virus integration site 1,Bmi-1)是抑制性多梳蛋白复合体1(polycomb repressor complex 1,PRC1)成员之一，PRC1通过调控染色质结构来调解静默基因，是正常细胞和肿瘤干细胞自我更新必不可少的基因。该文对Bmi-1在妇科肿瘤中作用的研究进展作一综述。 |
| 关键词: B细胞特异性莫罗尼鼠科白血病病毒集成位点1 妇科肿瘤 病理学 |
| DOI：10.3969/j.issn.1674-3806.2019.12.27 |
| 分类号:R 737 |
| 基金项目:广西卫健委科研课题（编号：Z2013282） |
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| Progress of research on polycomb group protein Bmi-1 in gynecological oncology |
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QIN Rui, NONG Wen-zheng, MO Qiu-rong
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Department of Gynecology, Minzu Hospital Affiliated to Guangxi Medical University, Nanning 530001, China
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| Abstract: |
| ［Abstract］ B cell-specific Moloney murine leukemia virus integration site 1(Bmi-1) is a member of the polycomb repressor complex 1(PRC1) that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells. This paper summarizes the progress of research on polycomb group protein, Bmi-1 in gynecological oncology. |
| Key words: B cell-specific Moloney murine leukemia virus integration site 1(Bmi-1) Gynecological oncology Pathology |
