引用本文:黄永塔(综述),莫祥兰(审校).miRNA与肿瘤转移调控机制的研究进展[J].中国临床新医学,2020,13(1):94-98.
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miRNA与肿瘤转移调控机制的研究进展
黄永塔(综述),莫祥兰(审校)
530021 南宁,广西壮族自治区人民医院病理科
摘要:
[摘要] 转移是恶性肿瘤的基本特征和重要标志,也是癌症患者治疗失败或死亡的首要原因。微小核糖核酸[micro ribonucleic acid(microRNA, miRNA)]是一类具有调控功能的非编码RNA片段,通过调控下游靶基因的转录和翻译,在肿瘤发生发展过程中发挥重要作用。miRNA参与恶性肿瘤侵袭及转移生物学行为中的多个重要环节,阐明肿瘤转移相关miRNA的转移调控机制,将为我们认识肿瘤发生发展提供新视角,给癌症的诊断和治疗带来新突破。该文对miRNA与肿瘤转移调控机制的研究进展进行综述。
关键词:  微小核糖核酸  肿瘤  转移  调控机制
DOI:10.3969/j.issn.1674-3806.2020.01.25
分类号:R 73-37
基金项目:国家自然科学基金项目(编号:81360355);广西卫健委科研课题(编号:Z2013355,Z2016590)
Research progress of regulation mechanisms in miRNA and tumor metastasis
HUANG Yong-ta, MO Xiang-lan
Department of Pathology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,China
Abstract:
[Abstract] Metastasis is the basic characteristics and important signs of malignant tumors, and also the primary cause of treatment failure or death of cancer patients.Micro ribonucleic acid(microRNA, miRNA) is a kind of non-coding RNA fragments with regulatory function. It plays an important role in tumorigenesis and development by regulating the transcription and translation of downstream target genes. miRNA plays an important role in the multiple important links in biological behavior of invasion and metastasis of malignant tumors. Elucidating the mechanisms of metastasis regulation of miRNA related to tumor metastasis will provide us with a new perspective on the occurrence and development of tumors and bring about a new breakthrough in the diagnosis and treatment of cancers. In this paper, we review the research progress of the regulation mechanisms in miRNA and tumor metastasis.
Key words:  Micro ribonucleic acid(microRNA, miRNA)  Tumors  Metastasis  Regulation mechanisms