| 摘要: |
| ［摘要］ 焦亡是一种新的程序性细胞死亡类型，它不同于凋亡和坏死，可以由各种细胞内或细胞外刺激引发。焦亡主要由Caspase-1/3/4/5/11和Gasdermin蛋白家族介导产生，具有细胞肿胀、胞膜溶解和炎症因子释放的特点。血液肿瘤亦称恶性血液病，包括急/慢性白血病、淋巴瘤、多发性骨髓瘤、骨髓增生异常综合征等，以恶性转化的造血干细胞异常分化和增殖为特征，是严重威胁人类健康的恶性疾病。近年来，随着细胞焦亡研究的兴起，很多学者通过对血液肿瘤中细胞焦亡机制的深入探究，发现血液肿瘤的新治疗靶点，并研究出相应的药物，揭示了焦亡在血液肿瘤发病机制中的作用，或将成为血液肿瘤的临床诊断、靶向治疗、预后评估的新方向。该文就焦亡的分子机制、焦亡在血液肿瘤中的相关研究进展进行综述，为更深入研究焦亡在血液肿瘤中的作用提供一些参考。 |
| 关键词: 焦亡 Caspase家族 Gasdermin家族 急性白血病 癌症治疗 |
| DOI：10.3969/j.issn.1674-3806.2021.02.02 |
| 分类号:R 733 |
| 基金项目:国家自然科学基金面上项目（编号：81974000） |
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| Molecular mechanism of pyroptosis and its research progress in hematological tumors |
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ZHENG Hong, ZHAO Ming-yi, YANG Ming-hua
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Department of Pediatrics, Xiangya Hospital of Central South University, Changsha 410008, China
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| Abstract: |
| ［Abstract］ Pyroptosis is a newly identified type of programmed cell death that is different from apoptosis and necrosis and can be initiated in response to various intracellular or extracellular stimuli. Pyroptosis is mainly mediated by Caspase-1/3/4/5/11 and Gasdermin family, and characterized by cell swelling, membrane lysis and release of pro-inflammatory factors. Hematological tumors, also known as malignant hematological diseases, including acute/chronic leukemia, lymphoma, multiple myeloma, myelodysplastic syndrome and so on, are characterized by abnormal differentiation and proliferation of malignant transformed hematopoietic stem cells. Hematological tumors are malignant diseases that seriously threaten human health. In recent years, with the rise of the study of pyroptosis, many scholars have found new therapeutic targets for hematological tumors and developed corresponding drugs through in-depth exploration of the mechanism of pyroptosis in hematological tumors, revealing the role of pyroptosis in the pathogenesis of hematological tumors, which may become a new direction of clinical diagnosis, targeted therapy and prognosis evaluation of hematological tumors. In this paper, we review the molecular mechanism of pyroptosis and the related research progress of pyroptosis in hematological tumors, so as to provide some references for further research on the role of pyroptosis in hematological tumors. |
| Key words: Pyroptosis Caspase family Gasdermin family Acute leukemia Cancer treatment |
