摘要: |
[摘要] 目的 根据前列腺特异性抗原(PSA)相关参数评估6针法和12针法两种活检策略的效果,为患者提供合适的个体化活检策略。方法 回顾性分析2013年3月至2019年11月在该院接受前列腺活检的525例疑似前列腺癌并接受前列腺穿刺活检患者的资料,比较不同穿刺策略的穿刺阳性率和高评分肿瘤检出率。结果 本研究共纳入525例患者,170例诊断为前列腺癌。其中331例血清总前列腺特异性抗原(tPSA)<20 ng/ml。当tPSA<20 ng/ml且前列腺体积(PV)≤60 ml时,12针法活检的穿刺阳性率高于6针法活检;当tPSA<20 ng/ml且前列腺特异性抗原密度(PSAD)≥0.15 ng/(ml·cc)时,12针法的穿刺阳性率也高于6针法。12针法活检在tPSA<20 ng/ml且经直肠超声(TRUS)阴性者中可发现更多的高评分肿瘤。此外,在tPSA<20 ng/ml且PV≤60 ml的患者中,12针法活检的高评分肿瘤检出率更高。结论 对于tPSA<20 ng/ml的患者,当PV≤60 ml、PSAD≥0.15 ng/(ml·cc)或合并正常超声结果的患者,推荐12针法活检方案。 |
关键词: 前列腺活检 前列腺特异性抗原 参数 |
DOI:10.3969/j.issn.1674-3806.2021.07.07 |
分类号:R 737.25 |
基金项目: |
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The value of prostate-specific antigen related parameters in prostate biopsy strategies: a single center′s retrospective study |
HUANG Gui-hai, LI Zuan, NONG De-yong, et al.
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The Second Department of Urology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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Abstract: |
[Abstract] Objective To evaluate the effects of two biopsy strategies, 6-core biopsy and 12-core biopsy, according to prostate-specific antigen(PSA) related parameters, and to provide appropriate individualized biopsy strategies for the patients. Methods The data of 525 patients who underwent prostate needle biopsy in the People′s Hospital of Guangxi Zhuang Autonomous Region from March 2013 to November 2019 due to suspected prostate cancer were analyzed retrospectively. The total cancer detection rate(CDR) and the high-grade cancer detection rate(HGCDR) were compared between the two different strategies of prostate needle biopsy. Results A total of 525 patients among whom 170 patients were diagnosed with prostate cancer were enrolled in this study, including 331 cases with serum total PSA(tPSA)<20 ng/ml. When tPSA<20 ng/ml and prostate volume(PV)≤60 ml, the CDR of 12-core biopsy was higher than that of 6-core biopsy. When tPSA<20 ng/ml and prostate-specific antigen density(PSAD)≥0.15 ng/(ml·cc), the CDR of 12-core biopsy was also higher than that of 6-core biopsy. The 12-core biopsy could help to find more high-grade cancers in patients with tPSA<20 ng/ml and negative transrectal ultrasound(TRUS). In addition, the HGCDR of the 12-core biopsy was higher in patients with tPSA<20 ng/ml and PV≤60 ml. Conclusion For patients with tPSA<20 ng/ml, 12-core biopsy is recommended when PV≤60 ml and PSAD≥0.15 ng/(ml·cc) or in combination with the normal TURS results. |
Key words: Prostate biopsy Prostate-specific antigen(PSA) Parameters |