| 摘要: |
| ［摘要］ 目的 采用静息态功能磁共振成像（fMRI）的分数低频振幅(fALFF)分析方法，探讨未经规范治疗的帕金森病(PD)患者大脑自发性活动强度变化及改变区域的空间分布情况。方法 招募2020年4月至2022年6月在该院神经内科就诊的未治疗PD患者33例（PD组），同时招募年龄、性别相匹配的健康志愿者34名作为健康对照组。采集两组全脑静息态fMRI数据。数据预处理后，计算全脑典型频段fALFF，并比较组间差异。为揭示频率相关信息的重要性，分别在Slow-5和Slow-4两个亚频段进行fALFF计算和组间比较。最后，提取PD患者显著改变脑区的fALFF值与Hoehn-Yahr（修订）分级进行相关性分析。结果 与健康对照组比较，在典型频段，PD组患者右侧颞上回、右侧中央前回、左侧颞上回、左侧扣带回存在fALFF改变，其中左侧扣带回fALFF值与Hoehn-Yahr（修订）分级呈负相关（r=-0.364，P=0.037）。在亚频段，PD患者组Slow-5频段的多个脑区存在fALFF改变，其中左侧舌回fALFF值与Hoehn-Yahr（修订）分级呈正相关（r=0.376，P=0.031），左侧扣带回fALFF值与Hoehn-Yahr（修订）分级呈负相关（r=-0.359，P=0.040）。结论 未经治疗PD患者存在与Hoehn-Yahr（修订）分级相关的自发性脑活动改变。亚频段fALFF值的更多发现为理解PD患者脑功能改变的病理生理机制提供了新的思路。 |
| 关键词: 帕金森病 功能磁共振成像 分数低频振幅 |
| DOI：10.3969/j.issn.1674-3806.2023.04.05 |
| 分类号:R 445.2；R 742.5 |
| 基金项目:江西省科技厅重点研发计划一般项目（编号：20202BBGL73103）；江西省临床医学研究中心组建项目（编号：20223BCG74001） |
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| Study on fractional amplitude of low-frequency fluctuation of cerebral resting-state functional magnetic resonance imaging in patients with untreated Parkinson′s disease |
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GONG Tao, CHENG Wei-ling, TAO Na, et al.
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Department of Radiology, Yichun People′s Hospital, Jiangxi 336000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the intensity alterations of brain spontaneous activity and the spatial distribution of altered regions in Parkinson′s disease(PD) patients without standard treatment by using the fractional amplitude of low-frequency fluctuation(fALFF) analysis method of resting-state functional magnetic resonance imaging(fMRI). Methods From April 2020 to June 2022, 33 untreated PD patients(the PD group) were recruited in the Department of Neurology of Yichun People′s Hospital, and at the same time 34 healthy volunteers roughly matched in age and gender were recruited as the healthy control group. The whole brain resting-state fMRI data were collected from the two groups. After the data were preprocessed, the whole brain typical frequency band fALFF was calculated, and the differences were statistically compared between the two groups. In order to reveal the importance of frequency-related information, the Slow-5 and Slow-4 sub-frequency bands of fALFF were calculated and compared. Finally, the fALFF values of the significantly altered brain areas in the PD patients were extracted for correlation analysis with Hoehn-Yahr(revised) grading scores. Results Compared with those in the healthy control group, the fALFF changes in the typical frequency band in the PD group were observed in the right superior temporal gyrus, right precentral gyrus, left superior temporal gyrus and left cingulate gyrus, and the fALFF values in the left cingulate gyrus were negatively correlated with the Hoehn-Yahr(revised) grading(r=-0.364, P=0.037). In the sub-frequency bands, the fALFF changes were found in several brain regions of the Slow-5 band in the PD group, among which the left lingual gyrus was positively correlated with the Hoehn-Yahr(revised) grading(r=0.376, P=0.031), and the left cingulate gyrus was negatively correlated with the Hoehn-Yahr(revised) grading(r=-0.359, P=0.040). Conclusion The intensity alterations of brain spontaneous activity which are related to Hoehn-Yahr(revised) grading scores are found in the untreated PD patients. More discoveries of fALFF values in sub-frequency bands provide new ideas for understanding the pathophysiological mechanism of brain functional alterations in PD patients. |
| Key words: Parkinson′s disease(PD) Functional magnetic resonance imaging(fMRI) Fractional amplitude of low-frequency fluctuation(fALFF) |
