| 摘要: |
| ［摘要］ 目的 探讨术前血小板-淋巴细胞比值（PLR）与浸润性乳腺癌非前哨淋巴结(SLN)转移的关联性。方法 回顾性分析2013年1月至2022年1月广西壮族自治区人民医院收治的280例前哨淋巴结活检(SLNB)阳性的浸润性乳腺癌患者的临床资料。通过多因素logistic回归分析非SLN转移的影响因素，通过受试者工作特征(ROC)曲线分析PLR对浸润性乳腺癌患者非SLN转移的预测效能。结果 ROC曲线分析结果显示，PLR具有预测浸润性乳腺癌患者非SLN转移的应用价值［AUC(95%CI)=0.569（0.508～0.627），P=0.046］，最佳截断值为134.85。多因素logistic回归分析结果显示，SLN转移数>1枚（OR=4.41）、有脉管浸润（OR=6.71）、人表皮生长因子受体2（HER2）阳性（OR=2.18）是非SLN转移的独立危险因素（P<0.05）；以PLR≤134.85为参考，PLR>134.85者非SLN转移风险更低（OR=0.56，P<0.05）。结论 治疗前PLR水平与浸润性乳腺癌非SLN转移具有关联性，应引起临床医师关注。 |
| 关键词: 乳腺癌 血小板-淋巴细胞比值 前哨淋巴结 |
| DOI：10.3969/j.issn.1674-3806.2023.06.08 |
| 分类号:R 737.9 |
| 基金项目:广西科技重大专项资助项目（编号：桂科AA22096018）；广西科技基地和人才专项（编号：桂科AD21220042） |
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| A study on the correlation between preoperative platelet-to-lymphocyte ratio and non-sentinel lymph node metastasis in invasive breast cancer |
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HUANG Kai, WEI Suo-su, HUANG Zhen, et al.
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Youjiang Medical University for Nationalities, Guangxi 533000, China; Department of Breast and Thyroid Surgery, the People′s Hospital of Guangxi Zhuang Autonomous Region(Guangxi Academy of Medical Sciences), Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the correlation between preoperative platelet-to-lymphocyte ratio(PLR) and non-sentinel lymph node(SLN) metastasis in invasive breast cancer. Methods The clinical data of 280 invasive breast cancer patients with positive sentinel lymph node biopsy who were admitted to the People′s Hospital of Guangxi Zhuang Autonomous Region from January 2013 to January 2022 were retrospectively analyzed. The influencing factors of non-SLN metastasis were analyzed by multivariate logistic regression, and the predictive efficacy of PLR for non-SLN metastasis in patients with invasive breast cancer was analyzed by receiver operating characteristic(ROC) curve. Results The results of ROC curve analysis showed that PLR had the application value of predicting non-SLN metastasis in patients with invasive breast cancer［AUC(95%CI)=0.569(0.508-0.627), P=0.046］, and its optimal cut-off value was 134.85. The results of multivariate logistic regression analysis showed that the number of SLN metastasis more than 1(OR=4.41), vascular infiltration(OR=6.71) and human epidermal growth factor receptor 2(HER2) positive(OR=2.18) were the independent risk factors for non-SLN metastasis(P<0.05). With PLR≤134.85 as reference, the risk of non-SLN metastasis was lower when PLR>134.85(OR=0.56, P<0.05). Conclusion The level of PLR before treatment is associated with non-SLN metastasis of invasive breast cancer, which should be concerned by clinicians. |
| Key words: Breast cancer Platelet-to-lymphocyte ratio(PLR) Sentinel lymph node(SLN) |
