| 摘要: |
| ［摘要］ 目的 分析成人及青少年弥漫硬化型甲状腺乳头状癌的临床病理特征。方法 回顾性分析2013年5月至2015年12月在天津医科大学肿瘤医院头颈外科收治的4 739例甲状腺乳头状癌患者的临床资料，其中36例为弥漫硬化型甲状腺乳头状癌。并对成人弥漫硬化型甲状腺乳头状癌及青少年弥漫硬化型甲状腺乳头状癌进行数据分析。结果 青少年弥漫硬化型甲状腺乳头状癌患者双侧发生率、弥散型率、侵出腺叶率、中央区淋巴结转移率及侧颈淋巴结转移率均高于成人患者，但差异无统计学意义（P>0.05）。两者仅颈部淋巴结复发率差异有统计学意义（P<0.05）。结论 大部分弥漫硬化型甲状腺乳头状癌患者为年轻患者，青少年弥漫硬化型甲状腺乳头状癌更易双侧发生，侵出腺叶及淋巴结转移率更高且相对于成人患者更易复发。 |
| 关键词: 弥漫硬化型甲状腺乳头状癌 青少年甲状腺癌 淋巴结转移 远处转移 |
| DOI：10.3969/j.issn.1674-3806.2023.08.03 |
| 分类号:R 736.1 |
| 基金项目:国家自然科学基金资助项目（编号：82272721）；天津市医学重点学科（专科）建设项目（编号：TJYXZDXK009A） |
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| Analysis on the clinicopathological features of diffuse sclerosing variant of papillary thyroid carcinoma in adults and adolescents |
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ZHANG Wei, LI Da-peng, CHENG Wen-yuan, et al.
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Department of Thyroid and Neck Cancer, Tianjin Medical University Cancer Hospital(National Clinical Research Center for Cancer, Tianjin Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy), Tianjin 300060, China
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| Abstract: |
| ［Abstract］ Objective To analyze the clinicopathological features of diffuse sclerosing variant of papillary thyroid carcinoma in adults and adolescents. Methods The clinical data of 4 739 patients with papillary thyroid carcinoma who were admitted to the Department of Head and Neck Surgery of Tianjin Medical University Cancer Hospital from May 2013 to December 2015 were retrospectively analyzed. Among these patients, 36 cases suffered from diffuse sclerosing variant of papillary thyroid carcinoma. The data of the adults and adolescents with diffuse sclerosing variant of papillary thyroid carcinoma were analyzed. Results The incidence rate of bilateral diffuse sclerosing variant of papillary thyroid carcinoma in the adolescent patients, and their diffuse lesion rate, extra-thyroidal invasion rate, central lymph node metastasis rate and lateral cervical lymph node metastasis rate were higher than those in the adults patients, but the differences were not significant(P>0.05). There was only significant difference in the recurrence rate of cervical lymph nodes between the two groups(P<0.05). Conclusion Most patients with diffuse sclerosing variant of papillary thyroid carcinoma are young patients, and diffuse sclerosing variant of papillary thyroid carcinoma is more likely to occur bilaterally in adolescents, with a higher rate of extra-thyroidal invasion and a rate of lymph node metastasis, and is more likely to recur in the adolescent patients than in the adult patients. |
| Key words: Diffuse sclerosing variant of papillary thyroid carcinoma Thyroid carcinoma in adolescents Lymph node metastasis Remote metastasis |
