| 摘要: |
| ［摘要］ 目的 分析肝移植术后人群新型冠状病毒奥密克戎变异株感染的临床表现和预后。方法 通过电话方式调查肝移植人群和慢性代偿性肝病人群感染奥密克戎变异株的416例患者的住院率。回顾性分析2022年12月至2023年2月新型冠状病毒奥密克戎变异株感染流行期间上海交通大学医学院附属瑞金医院和海军军医大学第二附属医院收治的35例新型冠状病毒阳性住院患者（6例肝移植术后，同期29例非肝移植患者）的临床资料，对其临床表现及预后转归情况进行比较。结果 移植人群和慢性代偿性肝病人群因奥密克戎变异株感染住院率分别为5.57%（16/287）和4.65%（6/129），差异无统计学意义（P>0.05）。肝移植组和非肝移植组住院患者年龄、发热、咳嗽等主要临床症状、临床分型、肺炎CT评分、住院天数、核酸转阴时间差异无统计学意义（P>0.05），住院时间≥2周和不良预后（接受有创呼吸支持或死亡）的人数比例差异亦无统计学意义（P>0.05）。结论 肝移植术后状态未显著影响奥密克戎变异株感染患者的临床表现、治疗及转归，肝移植手术史在奥密克戎变异株感染预后风险评估中的意义有限，有待进一步大样本研究。 |
| 关键词: 肝移植 新型冠状病毒 奥密克戎变异株 临床表现 预后 |
| DOI：10.3969/j.issn.1674-3806.2023.10.07 |
| 分类号:R 657.3 |
| 基金项目:国家自然科学基金资助项目（编号：82270681） |
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| Analysis on the clinical manifestations and prognosis of SARS-CoV-2 Omicron variant infection in populations after liver transplantation |
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ZHAN Jun-jie, ZHANG Lei, HANG Xiao-feng, et al.
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Department of Infection, the Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China
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| Abstract: |
| ［Abstract］ Objective To analyse the clinical manifestations and prognosis of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Omicron variant infection in populations after liver transplantation. Methods A telephone survey was conducted to investigate the hospitalization rates of the liver transplant population and the compensated chronic liver disease population(a total of 416 patients) infected with Omicron variant. A retrospective analysis of the clinical data of 35 hospitalized patients with positive SARS-CoV-2(six patients underwent liver transplantation and 29 patients underwent non-liver transplantation during the same period) who were admitted to Ruijin Hospital, Shanghai Jiao Tong University School of Medicine and the Second Affiliated Hospital of Naval Medical University during the epidemic period of SARS-CoV-2 Omicron variant infection from December 2022 to February 2023 was carried out, and the clinical manifestations and prognosis of the patients were compared. Results The incidence rates of hospitalization due to Omicron variant infection in the liver transplant population and the compensated chronic liver disease population were 5.57%(16/287) and 4.65%(6/129), respectively, with no statistically significant difference between the two populations(P>0.05). There were no statistically significant differences in age and major clinical symptoms such as fever and cough, clinical classification, pneumonia computed tomography(CT) scores, length of hospitalization, and nucleic acid negative conversion time between the liver transplantation group and the non-liver transplantation group(P>0.05), and there was also no statistically significant difference in the proportion of the patients with hospitalization time ≥2 weeks and poor prognosis(receiving invasive ventilator support or death) between the two groups(P>0.05). Conclusion The status after liver transplantation does not significantly affect the clinical manifestations, treatments, and outcomes of patients with Omicron variant infection. The significance of liver transplantation history in the prognosis assessment of Omicron variant infection is limited, and further large-scale studies are needed. |
| Key words: Liver transplantation Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Omicron variant Clinical manifestation Prognosis |
