| 摘要: |
| ［摘要］ 目的 探讨血清同型半胱氨酸（Hcy）、血尿酸（SUA）水平与腔隙性脑梗死患者动脉粥样硬化的相关性。方法 选取2012-11～2015-10该院住院的腔隙性脑梗死患者93例作为脑梗死组，根据超声检查结果分为动脉内膜中层厚度（IMT）正常组26例，IMT增厚组22例，斑块组45例三个亚组，另选择同期90名健康体检者作为正常对照组，比较各组间Hcy、SUA水平及IMT值，并分析指标间相关性。结果 脑梗死组血清Hcy、SUA水平均明显高于正常对照组（P<0.01）。脑梗死组内各亚组之间血清Hcy、SUA水平及IMT值比较差异均有统计学意义（P<0.05），其中IMT增厚组和斑块组各指标均明显高于IMT正常组（P<0.05），而斑块组各指标则均明显高于IMT增厚组（P<0.05）。经Pearson相关性分析显示腔隙性脑梗死患者IMT值与血清Hcy、SUA水平之间均呈正相关（P<0.05）。结论 腔隙性脑梗死患者血清Hcy、SUA水平明显增高，且血清Hcy、SUA水平升高与颈动脉粥样硬化的发生密切相关。 |
| 关键词: 腔隙性脑梗死 同型半胱氨酸 血尿酸 动脉粥样硬化 |
| DOI：10.3969/j.issn.1674-3806.2017.04.14 |
| 分类号:R 741 |
| 基金项目: |
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| The relationship between the levels of homocysteine, serum uric acid and carotid atherosclerotic plaques in patients with lacunar infarcts |
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LI Hai-hua
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Department of Neurology, the People′s Hospital of Fusui County, Guangxi 532199, China
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| Abstract: |
| ［Abstract］ Objective To explore the relationship between the levels of homocysteine(Hcy), serum uric acid(SUA) and carotid atherosclerotic plaques in patients with lacunar infarcts.Methods Ninety-three patients with lacunar infarcts in our hospital from November 2012 to October 2015 were collected as the cerebral infarction group, and they were divided into three subgroups according to the results of ultrasound: IMT normal group(n=26), IMT increased group(n=22) and plaque group(n=45). Ninety healthy people having medical examination in the same period were taken as the conthol group. The levels of Hcy, SUA and IMT were compared among the groups, and the relationships between the indexes were analyzed.Results The serum levels of Hcy and SUA in the cerebral infarction group were significantly higher than those in the control group（P<0.01）. There were significant differences in the serum levels of Hcy, SUA and IMT among the three subgroups（P<0.05）. All the indexes in the IMT increased group and the plaque group were significantly higher than those in the IMT normal group（P<0.05）, each index in the plaque group was significantly higher than that in the IMT increased group（P<0.05）. Pearson correlation test showed that there was a liner relationship between IMT value and the serum levels of Hcy, SUA in the patients with lacunar infarcts.Conclusion The serum levels of Hcy and SUA are obviously increased in the patients with lacunar infarcts. The carotid atherosclerotic plaques are associated with the high serum levels of Hcy and SUA. |
| Key words: Lacunar infarcts Homocysteine(Hcy) Serum uric acid(SUA) Carotid atherosclerotic plaques |
