| 摘要: |
| ［摘要］ 穿心莲内酯是自穿心莲中提取得到的二萜内酯类化合物,是穿心莲的主要活性成分之一。最近的研究表明，穿心莲内酯在抗肿瘤方面有巨大潜力，包括抑制肿瘤细胞活性，诱导肿瘤细胞凋亡，抑制肿瘤细胞周期进展、癌细胞转移和侵袭特性、生长因子信号传导调节，抑制细胞迁移和血管生成等，是一种新型抗肿瘤药物。该文就穿心莲内酯对不同癌症的作用及其机制的研究进展作一综述。 |
| 关键词: 穿心莲内酯 癌症 凋亡 周期停滞 治疗 |
| DOI：10.3969/j.issn.1674-3806.2017.07.33 |
| 分类号:R 730 |
| 基金项目: |
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| Research progress of andrographolide on anticarcinogenic action and its mechanism |
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CHEN Bo-yi, QU Li-li, LIU Jian-sheng
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Research progress of andrographolide on anticarcinogenic action and its mechanism
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| Abstract: |
| ［Abstract］ Andrographolide is a bioactive diterpenoid extracted from a traditional herbal medicine named andrographis paniculata. Previous studies show that andrographolide has antitumor activity. Its antitumor mechanisms include cell apoptosis, cell cycle arrestment, growth factor signaling modulation, suppressing cellular migration and angiogenesis. Andrographolide is a potentially novel natural antitumor medicine. The research progress of andrographolide on anticarcinogenic action and its mechanisms is reviewed in this paper. |
| Key words: Andrographolide Cancer Apoptosis Cell cycle arrestment Treatment |
