| 摘要: |
| ［摘要］ 目的 探讨热性惊厥(febrile seizures，FS)患儿血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平变化，分析三者在FS患儿血清中水平的相关性，进一步研究它们与儿童FS发病的关系。方法 选取2016-07～2017-07该院收治的72例FS患儿，将其分为单纯性热性惊厥(SFS)组40例和复杂性热性惊厥(CFS)组32例。选取同期在该院体检且年龄和性别相匹配的50名儿童作为健康对照组。采用双抗体夹ELISA法对血清中IL-1β、IL-6、TNF-α的水平进行测定。结果 FS组患儿血清IL-1β、IL-6及TNF-α水平均高于健康对照组，差异均有统计学意义（P<0.05）；SFS组患儿血清IL-1β、IL-6及TNF-α水平均低于CFS组，差异均有统计学意义（P<0.05）；IL-1β、IL-6及TNF-α在FS患儿血清中的水平均呈正相关（P均<0.05）。结论 儿童血清IL-1β、IL-6及TNF-α水平升高与FS发生密切相关，三者有协同作用。 |
| 关键词: 儿童 热性惊厥 白细胞介素-1β 白细胞介素-6 肿瘤坏死因子-α |
| DOI：10.3969/j.issn.1674-3806.2018.06.02 |
| 分类号:R 72 |
| 基金项目:河南省医学科技攻关计划项目（编号：201702102） |
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| Changes of IL-1β, IL-6 and TNF-α and correlation of the changes with febrile seizures in children |
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CHEN Hao, PAN Yang-Qiong, ZHANG Xiang-Min, et al.
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Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University, Henan 450052, China
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| Abstract: |
| ［Abstract］ Objective To investigate the changes of interleukin-1β（IL-1β）, interleukin-6(IL-6) and tumour necrosis factor-alpha(TNF-α) and the correlation of the changes with febrile seizures(FS) in children. Methods 72 children with FS were divided into the simple FS(SFS) group(n=40) and the complex FS(CFS) group(n=32). 50 healthy children with matched age and sex were taken as the control group. Enzyme Linked Immunosorbent Assay(ELISA) was used to detect the serum levls of IL-1β, IL-6 and TNF-α. Results The levels of serum IL-1β, IL-6 and TNF-α in the FS group were all significantly higher than those in the healthy control group(P<0.05). The levels of serum IL-1β, IL-6 and TNF-α in the SFS group were all significantly lower than those in the CFS group(P<0.05). There was a positive correlation between the levels of IL-1β, IL-6 and TNF-α and FS in children(P<0.05). Conclusion The increased levels of IL-1β, IL-6 and TNF-α are correlated with the attack of FS, and have a synergistic effect on FS. |
| Key words: Children Febrile seizures(FS) Interleukin-1β（IL-1β） Interleukin-6(IL-6) Tumour necrosis factor-alpha(TNF-α) |
