| 摘要: |
| ［摘要］ 目的 探讨戊酸雌二醇地诺孕素治疗月经过多患者的疗效及安全性。方法 选取2017-01～2018-12该院收治的月经过多患者60例，采用随机数字表法随机分为对照组和观察组，每组30例。对照组采用戊酸雌二醇+黄体酮治疗，观察组采用戊酸雌二醇地诺孕素治疗，对比两组临床疗效、月经量变化情况、血红蛋白水平变化情况及不良反应发生率。结果 观察组治疗总有效率（93.33%）较对照组（73.33%）高，差异有统计学意义（P<0.05）；治疗3个月及6个月后，两组患者月经量均减少，观察组较对照组下降趋势更显著（P<0.05）；与治疗前相比，治疗后两组的血红蛋白水平均提升，且治疗后观察组血红蛋白水平较对照组高，差异有统计学意义（P<0.05）；两组不良反应发生率比较差异无统计学意义（P>0.05）。结论 戊酸雌二醇地诺孕素能够有效治疗月经过多，减少月经出血量，提升血红蛋白水平。 |
| 关键词: 月经过多 戊酸雌二醇地诺孕素 疗效 安全性 |
| DOI：10.3969/j.issn.1674-3806.2020.02.10 |
| 分类号:R 711.51 |
| 基金项目:广西卫健委科研课题（编号：Z20170335） |
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| Study on the efficacy and safety of estradiol valerate dienogest in treatment of menorrhagia |
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YANG Liu, ZHAO Ren-feng, XU Li-li, et al.
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Department of Gynecology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To explore the efficacy and safety of estradiol valerate dienogest in treatment of menorrhagia. Methods Sixty patients with menorrhagia admitted to our hospital from January 2017 to December 2018 were randomly divided into control group and observation group by random number table method, with 30 cases in each group.The control group was treated with estradiol valerate+progesterone, and the observation group was treated with estradiol valerate dienogest. The clinical efficacy, the changes of menstrual volume and hemoglobin, and adverse reactions were compared between the two groups. Results The effective rate of the observation group(93.33%) was significantly higher than that of the control group(73.33%)(P<0.05). After 3 and 6 months of treatment, the amount of menstruation in the two groups decreased, and the trend of decrease in the observation group was more significant than that in the control group(P<0.05). Compared with those before treatment, the hemoglobin levels of the two groups after treatment increased, and the hemoglobin level of the observation group after treatment was significantly higher than that of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Estradiol valerate dienogest can effectively treat menorrhagia, reduce the amount of menstrual bleeding and improve the level of hemoglobin. |
| Key words: Menorrhagia Estradiol valerate dienogest Efficacy Safety |
