| 摘要: |
| ［摘要］ 肝缺血再灌注损伤（HIRI）是传统肝移植术中不可避免的病理生理过程，其严重程度受到来自供体和受体的多方面因素影响，最严重者可导致术后早期移植肝无功能。人骨髓间充质干细胞（BMSCs）及其外泌体已在临床试验中被证实具有促进组织修复与免疫调节的能力，这一治疗作用在HIRI的防治中具有较好的应用前景。该文旨在综述BMSCs及其外泌体在移植肝HIRI防治中潜在作用机制的研究进展及未来研究方向。 |
| 关键词: 肝缺血再灌注损伤 肝移植 人骨髓间充质干细胞 外泌体 |
| DOI：10.3969/j.issn.1674-3806.2024.04.06 |
| 分类号:R 657.3 |
| 基金项目:国家自然科学基金项目（编号：81974081） |
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| Research progress on the therapeutic potential effects of human bone marrow mesenchymal stem cells and their exosomes in the treatment of hepatic ischemia-reperfusion injury after liver transplantation |
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ZHANG Yihan, YAO Weifeng
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Center of Surgery and Anesthesiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China
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| Abstract: |
| ［Abstract］ Hepatic ischemia-reperfusion injury(HIRI) is an inevitable pathophysiological process during traditional liver transplantation. Its severity can be affected by multiple factors involving both donors and recipients, and the most severe consequence can be early post-operative graft dysfunction. Human bone marrow mesenchymal stem cells(BMSCs) and their exosomes have been proven to be capable of promoting tissue regeneration and immune modulation in clinical trials, therefore, they have promising prospects in treating and preventing HIRI. We aim to review the current research progress in the potential mechanism as well as the future research direction of BMSCs and their exosomes in the prevention and treatment of HIRI. |
| Key words: Hepatic ischemia-reperfusion injury(HIRI) Liver transplantation Human bone marrow mesenchymal stem cells(BMSCs) Exosome |
