| 摘要: |
| 研究证实动脉粥样硬化性心血管事件与慢性肾功能不全紧密相关，认为肾小球滤过率（eGFR）是冠脉狭窄程度的独立预测因子，而肾功能水平下降本身是否是动脉粥样硬化的危险因素仍存争议。本文将从以下三个方面对冠脉病变严重程度与肾功能水平相关性的研究进展进行综述：1.冠脉病变与肾功能不全相关性的临床研究证据。2.冠心病合并慢性肾功能不全者临床预后的相关性。3.动脉粥样硬化与肾功能不全的可能病理生理学机制。 |
| 关键词: 冠心病 冠脉狭窄 肾小球滤过率 综述 |
| DOI： |
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| 基金项目:1.广西医药卫生自筹经费计划课题项目（No：Z2015310）；2.广西科学研究与技术开发计划项目（No：桂攻科14124003-9） |
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| The Advancement Of Correlation Between Severity Of Coronary Artery Stenosis And Estimated Glomerular Filtration Rate |
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熊日新
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The People's Hospital of Guangxi Zhuang Autonomous Region
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| Abstract: |
| It is known that there is a close relationship between chronic kidney dysfunction and atherosclerosis cardiovascular diseases. Estimated Glomerular Filtration Rate (eGFR) is considered as an independent predictor of coronary stenosis severity, however, whether the decrease of renal function per se is the risk factor of atherosclerosis is still controversial. We aim to review the correlation between the severity of coronary artery stenosis and eGFR as following: First, the clinical evidences of chronic kidney dysfunction and the coronary artery leisions. Second, the prognosis of coronary heart disease(CHD) patients with chronic kidney dysfunction. Third, the potential pathophysiology mechanisms of atherosclerosis and kidney dysfunction. |
| Key words: coronary artery stenosis eGFR Review |
