| 摘要: |
| 目的 观察中药内服联合隔姜艾灸治疗Hp阳性慢性萎缩性胃炎(CAG)伴肠化的临床疗效。方法 将92例患者采用 SAS 软件生成的随机表分为观察组与对照组各46例。两组均给予铋剂四联根除方案进行常规治疗。对照组在常规治疗基础上给予叶酸治疗。观察组在对照组的基础上给予中药内服+隔姜艾灸。两组均连续治疗12周。观察两组治疗前后的中医证候积分、血清胃蛋白酶原(PG)I、PGII、PGR(PGI/PGII)、胃泌素-17(G-17)水平。治疗结束1个月后复查胃镜和幽门螺杆菌(Hp),比较两组的临床效果。结果 观察组的临床总有效率为91.30%,Hp转阴率为 93.48%,明显优于对照组(P＜0.05),中医证候积分、胃黏膜炎症、腺体萎缩及肠化积分均明显下降,血清PGI、PGR比值和G-17水平均升高,PGII水平降低明显低于治疗前,且观察组优于对照组 (P＜0.05)。两组均无明显不良反应。结论 中药内服联合隔姜艾灸治疗CAG伴肠化患者疗效显著,可有效改善患者临床症状,降低炎性反应,保护胃黏膜，改善胃黏膜萎缩及肠化,促使HP转阴,且安全可靠,值得临床进一步研究探讨。 |
| 关键词: 萎缩性胃炎 肠化 Hp 中药内服 隔姜灸 |
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| Clinical Observation on Treatment of Hp-positive chronic atrophic gastritis with intestinal metaplasia with Oral Chinese Medicine Combined with Ginger moxibustion |
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Jiang Rui,Yuan xiang-ke
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The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine
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| Abstract: |
| Objective To observe the clinical efficacy of traditional Chinese medicine combined with ginger and moxibustion for the treatment of Hp-positive chronic atrophic gastritis (CAG) with intestinal metaplasia.Methods A total of 92 patients were randomly divided into observation group and control group by 46 cases. Both groups were given routine treatment with tincture quadruple eradication. The control group received folic acid treatment on the basis of conventional treatment. The observation group was given traditional Chinese medicine on the basis of the control group, and the two groups were treated continuously for 12 weeks. TCM syndrome scores before and after treatment, serum pepsinogen (PG) I, PGII, PGR (PGI/PGII), gastrin-17 (G-17) levels, and gastroscope and pylorus were reviewed 1 month after treatment Helicobacter pylori (Hp), comparing the clinical effects of the two groups. Results The total effective rate of the observation group was 91.30%, and the Hp conversion rate was 93.48%, which was significantly better than the control group (P<0.05). The TCM syndrome score, gastric mucosal inflammation, gland atrophy and intestinal metastasis were all obvious. Decreased, serum PGI, PGR ratio and G-17 level increased, PGII level decreased significantly lower than before treatment, and the observation group was superior to the control group (P<0.05). There were no significant adverse reactions in either group. Conclusion Chinese herbal medicine combined with ginger moxibustion for treating CAG with intestinal metastasis has significant curative effect, which can effectively improve clinical symptoms, reduce inflammatory reaction, protect gastric mucosa, improve gastric mucosal atrophy and intestinal metaplasia, and promote HP to be negative, and safe and reliable. It is worthy of further clinical research. |
| Key words: Atrophic gastritis Intestinalization Hp Oral Chinese Medicine Ginger moxibustion |
