| 摘要: |
| 阻塞性睡眠呼吸暂停（Obstructive sleep apnea，OSA）是一种常见的睡眠相关呼吸系统疾病，慢性间歇性缺氧可以导致全身炎症，并激活各种炎症通路，进而加重OSA。炎症细胞因子是一类细胞信号分子，通过自分泌、旁分泌和内分泌等方式进行信息传递。OSA和全身炎症以及炎症细胞因子之间联系密切，包括TNF-α、IL-33、IL-17、IL-10、IL-1β、IL-6和IL-8等在内的炎症细胞因子均被证实参与了OSA的发病过程，并促进炎症通路的再激活。本文对近年来炎症细胞因子与OSA发生发展的研究进展进行综述。 |
| 关键词: 阻塞性睡眠呼吸暂停 炎症细胞因子 TNF-α IL 炎症反应 |
| DOI： |
| 分类号: |
| 基金项目:山东省医药卫生科技发展计划项目(编号:2019WS328) |
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| Research progress between inflammatory cytokines and the development of obstructive sleep apnea |
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Li Dongyang
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Binzhou Medical University Hospital
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| Abstract: |
| Obstructive sleep apnea ( OSA) is a common sleep-related respiratory disease. Chronic intermittent hypoxia can lead to systemic inflammation and activation of various inflammatory pathways aggravating the severity of OSA. Inflammatory cytokines are a class of cell signaling molecules that transmit information through the means of autocrine, paracrine and endocrine. OSA is closely associated with systemic inflammation and inflammatory cytokines. Inflammatory cytokines including TNF-α, IL-10, IL-1β, IL-6, IL-8, IL-33 and IL-17 have all been confirmed to contribute to the pathogenesis of OSA and promote the reactivation of inflammatory pathways. The paper reviews the research progress between inflammatory cytokines and the development of obstructive sleep apnea in recent years. |
| Key words: Inflammatory cytokinine Obstructive sleep apnea TNF-α IL Inflammatory response |
