| 引用本文: | 王娅鑫,钱净,杨文迪,朗迪,马永鑫,张鸿伟,黎海生,赵晓丽.FDP、D-D、Fib联合PLT计数在创伤性凝血病中的预后价值分析[J].中国临床新医学,0,():-. |
| wangyaxin,qianjing,yangwendi,langdi,mayongxin,zhanghongwei,lihaisheng.FDP、D-D、Fib联合PLT计数在创伤性凝血病中的预后价值分析[J].中国临床新医学,0,():-. |
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| FDP、D-D、Fib联合PLT计数在创伤性凝血病中的预后价值分析 |
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王娅鑫,钱净,杨文迪,朗迪,马永鑫,张鸿伟,黎海生,赵晓丽
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昆明市第一人民医院
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| 摘要: |
| 目的 探究FDP、D-D、Fib联合PLT计数在创伤性凝血病(TIC)中的临床预后价值。方法 回顾性分析2020年2月至2023年2月昆明市第一人民医院急诊科的182例多发伤患者的资料,根据患者是否发生TIC,分为TIC组85例(存活59例,死亡26例)和非TIC组97例。比较不同组的临床资料,通过多因素logistic回归分析探讨TIC患者入院首次FDP、D-D、PLT计数指标对疾病预后的预测价值。最后采用ROC曲线比较入院首次FDP、D-D、Fib、PLT计数及联合检测时对TIC患者入院后30天内死亡的预测价值。结果 同非TIC组相比,TIC组患者入院时首次ISS评分、PT、PTR、INR、APTT、TT、FDP、D-D均显著升高(P<0.05),而Fib、Hb、PLT计数量均显著下降(P<0.05)。通过多因素分析提示,入院首次FDP、D-D、PLT与TIC具有显著相关性。根据入院首次ROC曲线分析得FDP、D-D、FDP/Fib、D-D/Fib对TIC的预后有预测价值,其中D-D曲线下面积最大为0.757。结论 FDP、D-D和PLT计数是影响TIC患者死亡的独立危险因素。入院首次FDP、D-D、FDP/Fib、D-D/Fib对TIC患者30天内预后具有较好的预测价值。 |
| 关键词: 创伤性凝血病 预后 Fib FDP D-D PLT |
| DOI： |
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| 基金项目:云南省科技厅科技计划项目(编号:202301AY070001-097)；云南省科技厅重大科技专项计划项目(编号：202302AA310018-C-7) |
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| The prognostic value of Fib, FDP, D-D combined with PLT count in traumatic coagulopathy |
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wangyaxin1,2,2,3, qianjing, yangwendi, langdi, mayongxin, zhanghongwei, lihaisheng
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1.the First People&2.'3.s Hospital of Kunming
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| Abstract: |
| Objective Investigating the clinical prognostic value of FDP, D-Dimer, and Fib combined with PLT count in traumatic coagulopathy (TIC). Methods A retrospective analysis was conducted on data from 182 patients with multiple injuries admitted to the Emergency Department of the First People"s Hospital of Kunming City from February 2020 to February 2023. Based on whether the patients developed traumatic coagulopathy (TIC), they were divided into two groups: TIC group (85 cases, with 59 survivors and 26 deaths) and non-TIC group (97 cases). Clinical data between the two groups were compared, and the predictive value of initial FDP, D-Dimer, and PLT count in TIC patients" prognosis was explored through multivariable logistic regression analysis. Finally, ROC curves were used to compare the predictive value of initial FDP, D-Dimer, Fib, PLT count, and combined detection for mortality within 30 days after admission in TIC patients. Results Compared with the non-TIC group, patients in the TIC group had significantly higher initial ISS scores, PT, PTR, INR, APTT, TT, FDP, and D-Dimer levels upon admission (P<0.05), while Fib, Hb, and PLT counts were significantly lower (P<0.05). Multivariate analysis indicated a significant correlation between initial FDP, D-Dimer, PLT count, and TIC. According to the ROC curve analysis of the initial values, FDP, D-Dimer, FDP/Fib, and D-Dimer/Fib showed predictive value for the prognosis of TIC, with the largest area under the curve (AUC) being 0.757 for D-Dimer. Conclusions FDP, D-Dimer, and PLT count are independent risk factors that affect mortality in TIC patients. The initial values of FDP, D-Dimer, FDP/Fib, and D-Dimer/Fib upon admission have good predictive value for the prognosis of TIC patients within 30 days. |
| Key words: traumatic coagulopathy Prognostic value Fib FDP D-D PLT |
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