| 引用本文: | 李朝威,徐军发,郑碧英.结核分枝杆菌感染巨噬细胞中缺氧诱导因子1α对其能量代谢的调控作用研究进展[J].中国临床新医学,0,():-. |
| Li Chaowei,Xu Junfa.结核分枝杆菌感染巨噬细胞中缺氧诱导因子1α对其能量代谢的调控作用研究进展[J].中国临床新医学,0,():-. |
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| 摘要: |
| 巨噬细胞作为机体免疫系统的重要组成部分,其通过能量代谢直接影响宿主体内清除结核分枝杆菌(Mycobacterium tuberculosis,Mtb)的能力。缺氧诱导因子1α(HIF-1α)通过影响巨噬细胞内的能量代谢途径来调控细胞对Mtb的免疫应答,在巨噬细胞抗结核免疫中起重要作用。本综述总结了结核菌感染中巨噬细胞能量和及其代谢变化,强调了HIF-1α在调控能量代谢和转化中的核心作用。通过深入理解巨噬细胞的代谢途径及其在结核感染中的作用,可能为开发针对结核病的新型治疗策略提供重要的科学依据。 |
| 关键词: 结核分枝杆菌 缺氧诱导因子1α 信号通路 治疗靶点 |
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| 基金项目:国家自然科学基金(82270013)；广东省教育厅创新团队项目(2022KCXTD010) |
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| Advancements in the Study of Hypoxia-Inducible Factor 1-alpha's Regulatory Effects on Energy Metabolism in Macrophages Infected by Mycobacterium Tuberculosis |
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Li Chaowei, Xu Junfa
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Guangdong Medical Univerisity
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| Abstract: |
| Macrophages, as integral components of the body's immune system, directly influence the host's ability to clear Mycobacterium tuberculosis (Mtb) through energy metabolism. Hypoxia-inducible factor 1-alpha (HIF-1α) serves as a central orchestrator in the immune response against Mtb by regulating energy metabolic pathways within macro-phages. This review presents a comprehensive synthesis of the alterations occurring in macrophage energy metabolism during tuberculosis infection, emphasizing the pivotal role of HIF-1α in this process. A thorough comprehension of macrophage metabolic pathways and their implications in tuberculosis infection offers promising avenues for the development of innovative therapeutic strategies targeting this disease. |
| Key words: Mycobacterium tuberculosis Hypoxia-inducible factor 1-alpha Signaling pathways Therapeutic targets |
