| 引用本文: | 胡邀时,陆政德,张朝勇.铁死亡在心血管疾病中的研究进展[J].中国临床新医学,0,():-. |
| Huyaoshi,Luzhengde.铁死亡在心血管疾病中的研究进展[J].中国临床新医学,0,():-. |
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| 摘要: |
| 细胞死亡在疾病病理生理进程中扮演着关键角色，深入解析其发生机制及调控网络具有重要的科学意义。铁死亡（ferroptosis）作为一种新型程序性细胞死亡方式，以铁离子依赖性脂质过氧化累积为核心特征。近年研究表明，铁死亡参与调控多种心血管疾病的病理进程，并可能成为潜在的干预靶点。本文系统综述铁死亡的关键分子调控机制，重点探讨其在心血管疾病中的病理作用及其转化医学价值，以期为相关疾病的防治提供新的理论依据。 |
| 关键词: 铁死亡 心血管疾病 脂质过氧化 分子机制 |
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| 基金项目:广西医科大学青年科学基金资助项目(编号：GXMUYSF 202541)；广西高校中青年教师科研基础能力提升项目(编号：2025KY0118) |
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| Research Progress of Ferroptosis in Cardiovascular Diseases |
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Huyaoshi,Luzhengde
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Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University
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| Abstract: |
| Cell death plays a crucial role in the pathophysiological processes of diseases, and in-depth dissection of its mechanisms and regulatory networks holds significant scientific importance. Ferroptosis, a novel form of regulated cell death, is characterized by the accumulation of iron-dependent lipid peroxidation. Recent studies have shown that ferroptosis is involved in the pathological processes of various cardiovascular diseases and may serve as a potential therapeutic target. This review systematically summarizes the key molecular regulatory mechanisms of ferroptosis, with a focus on its pathological roles in cardiovascular diseases and its translational medical value, aiming to provide new theoretical basis for the prevention and treatment of related diseases. |
| Key words: Ferroptosis Cardiovascular diseases Lipid peroxidation Molecular mechanisms |
