引用本文:钟金媚，梁业金，蒋玉洁.Nur77在急性呼吸窘迫综合征发病机制中的作用研究进展[J].中国临床新医学,2026,19(1):101-105.
【打印本页】   【下载PDF全文】   【查看/发表评论】  【EndNote】   【RefMan】   【BibTex】
←前一篇|后一篇→ 过刊浏览    高级检索
本文已被：浏览 40次   下载 67次 本文二维码信息
码上扫一扫！
分享到： 微信 更多
字体:加大+|默认|缩小-
Nur77在急性呼吸窘迫综合征发病机制中的作用研究进展
钟金媚1，2，梁业金1，3，蒋玉洁4
1.右江民族医学院研究生学院，百色 533000；2.右江民族医学院附属医院重症医学科，百色 533000；3.右江民族医学院附属医院血液内科，百色 533000；4.右江民族医学院附属医院呼吸与危重症医学科，百色 533000
摘要:
［摘要］　急性呼吸窘迫综合征（ARDS）是一种严重威胁生命的急危重症。近年来，核受体蛋白Nur77在ARDS发病机制中的作用逐渐受到关注。Nur77作为一种核转录调控蛋白，分布于多种组织和细胞中。其表达受多种外界刺激的影响，通过调控代谢重编程、免疫稳态平衡以及炎症信号转导等多种机制参与ARDS病理生理过程。该文对Nur77在ARDS发病机制中的作用研究进展作一综述。
关键词:  Nur77  急性呼吸窘迫综合征  炎症  凋亡  修复
DOI：10.3969/j.issn.1674-3806.2026.01.17
分类号:R 563
基金项目:国家自然科学基金项目（编号：81860021）；广西自然科学基金项目（编号：2021GXNSFAA325003）
Research progress in the role of Nur77 in pathogenesis of acute respiratory distress syndrome
ZHONG Jinmei1,2, LIANG Yejin1,3, JIANG Yujie4
1.Graduate School, Youjiang Medical University for Nationalities, Baise 533000, China; 2.Department of Critical Care Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China; 3.Department of Hematology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China; 4.Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China
Abstract:
［Abstract］　Acute respiratory distress syndrome(ARDS) is a life-threatening critical illness. In recent years, the role of nuclear receptor neuron-derived clone 77(Nur77) in pathogenesis of ARDS has gradually attracted attention. Nur77, as a nuclear transcriptional regulatory protein, is widely distributed in various tissues and cells. The expression of Nur77 is influenced by various external stimuli. Nur77 is involved in the pathophysiological processes of ARDS by regulating multiple mechanisms such as metabolic reprogramming, immune homeostasis balance, and inflammatory signal transduction. In this paper, the research progress in the role of Nur77 in pathogenesis of ARDS is reviewed.
Key words:  Neuron-derived clone 77(Nur77)  Acute respiratory distress syndrome(ARDS)  Inflammation  Apoptosis  Repair