| 摘要: |
| ［摘要］ 随着精准医学和靶向治疗的飞速发展，卵巢癌的治疗模式正经历从“经验外科”向“全程慢病化管理”的深刻转型。该文结合最新临床证据与指南，系统梳理卵巢癌全生命周期管理的路径，探讨适合我国国情的规范化诊疗与防控策略。全生命周期管理强调以患者为中心，涵盖了从遗传风险评估、精准初治、靶向维持、复发管理到康复与临终关怀的全过程。多学科协作和分级诊疗是实现这一目标的核心抓手，通过构建分层筛查体系、规范化多学科协作及完善康复支持网络，有望将卵巢癌真正转变为可防、可控、可治的“慢性病”，实现患者生存获益最大化。 |
| 关键词: 卵巢癌 全生命周期管理 精准治疗 分级诊疗 姑息治疗 |
| DOI：10.3969/j.issn.1674-3806.2026.08.02 |
| 分类号:R 737.31 |
| 基金项目:上海市科学技术委员会科技计划项目（编号：23JC1403000）；上海交通大学医工交叉青年项目（编号：24X010301423） |
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| Whole-life-cycle management of ovarian cancer: advancements and insights from conceptual innovation to clinical practice |
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Zhang Nan, Di Wen
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Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Gynecologic Oncology, Shanghai 200127, China
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| Abstract: |
| ［Abstract］ Driven by rapid advancements in precision medicine and targeted therapies, the treatment paradigm for ovarian cancer(OC) is undergoing a profound transformation from “empirical surgery” to “comprehensive chronic disease management”. Based on the updated clinical evidence and guidelines, this paper systematically outlines the pathway for whole-life-cycle management of OC, and explores standardized diagnosis, treatment, and prevention strategies tailored to the Chinese healthcare context. Whole-life-cycle management emphasizes patient-centered care, covering a continuum of care spanning genetic risk assessment, precision initial treatment, targeted maintenance therapy, relapse management, rehabilitation, and palliative care. Multidisciplinary team(MDT) collaboration and a tiered diagnosis and treatment system serve as the core pillars to achieve this goal. By establishing a stratified screening system, standardizing MDT collaboration and improving the rehabilitation support network, it is expected to truly transform OC into a preventable, controllable, and treatable “chronic disease”, thereby maximizing survival benefits for the patients. |
| Key words: ovarian cancer(OC) whole-life-cycle management precision medicine tiered diagnosis and treatment system palliative care |
