| 摘要: |
| ［摘要］ Caspase-3是凋亡级联反应中最关键的下游效应蛋白，在细胞凋亡过程中发挥核心作用。它通过激活核酸内切酶引发DNA片段化，最终导致细胞程序性死亡。该文系统阐述Caspase-3的生理功能，包括作为神经元细胞凋亡的关键执行因子、参与tau蛋白切割，以及在线粒体凋亡途径中的核心作用，并综述其在脑缺血再灌注损伤、中枢神经系统感染、多发性硬化症、阿尔茨海默病以及急性脊髓损伤等神经系统疾病中的研究进展，旨在为神经系统疾病的治疗策略提供新思路。 |
| 关键词: 神经系统疾病 Caspase-3 神经元细胞凋亡 tau蛋白 线粒体凋亡途径 |
| DOI：10.3969/j.issn.1674-3806.2026.08.21 |
| 分类号:R 741 |
| 基金项目:内蒙古自治区科技计划项目（编号：2025YFSH0059）；内蒙古自治区人民医院公立医院科研联合基金科技项目（编号：2024GLLH0085） |
|
| Research progress of Caspase-3 in central nervous system diseases |
|
Ma Chunping1, Su Xuewen2
|
| Abstract: |
| ［Abstract］ Caspase-3 is the most critical downstream effector protein in apoptotic cascades and plays a central role in the process of cell apoptosis. Caspase-3 triggers DNA fragmentation by activating endonucleases, ultimately leading to programmed cell death. This paper elaborates on the physiological functions of Caspase-3, including its role as a key executioner in neuronal apoptosis, its ability to cleave tau protein, and its central role in the mitochondrial apoptotic pathway, and reviews the research progress of Caspase-3 in neurological diseases such as cerebral ischemia-reperfusion injury, central nervous system infection, multiple sclerosis, Alzheimer′s disease, and acute spinal cord injury, aiming to provide novel therapeutic strategies for neurological diseases. |
| Key words: neurological diseases Caspase-3 neuronal apoptosis tau protein mitochondrial apoptotic pathway |
