| 摘要: |
| ［摘要］ 冠心病（CHD）的诊断及治疗技术在近年来有了很大进展，但对其病因学研究进展缓慢。最近大量的临床病理和流行病学研究结果显示，感染与冠心病的发生发展有关，包括细菌（幽门螺旋杆菌、流感噬血杆菌、链球菌等）、病原体（肺炎衣原体、支原体）和病毒（巨细胞病毒、单纯疱疹病毒、EB病毒、甲肝病毒、艾滋病毒、乙肝病毒等）在内的病原微生物可能是CHD发病的感染因素，感染物质可能影响粥样斑块的稳定性，细胞因子如TNF、IL-6、CRP及黏附分子等表达增强，诱发加重血管内皮损伤，加速动脉硬化的形成发展为冠心病。抗生素治疗冠心病取得一定的进展，主要是针对肺炎衣原体和幽门螺旋杆菌感染的治疗。 |
| 关键词: 冠心病 感染 抗生素 |
| DOI：10.3969/j.issn.1674-3806.2009.05.010 |
| 分类号:R 541.4 |
| 基金项目: |
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| The relation between infection and coronary heart diseasea and application of antibotic in the treatment of coronary heart diseasea |
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DUAN-hao, LIN Feng-xian, ZHANG Hong-kao, et al.
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Department for First Internal Medicine of Hospital of Luoyang Iron (Group), Luoyang 471023, China
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| Abstract: |
| ［Abstract］ The digonositic or trement level of coronary heart disease(CHD) has made great development, but the pathogeny is still unknowen.Revently a large evidence of study in pathology manifest there is a link between chornic infection and coronary heart disease. Pathogenic microorganisms, including pathogen(Chlamydia pneumoniae, CPn;Mycoplasma pneumoniae, MPn), virus(Cytomegalvirus, CMV;Herpes simplex virus, HSV;Enstein-Berrvirus, EBV;HAV, HIV, HBV, Influenzavirus), bacterium (Helicobacter pylori, HP;Streptococcus, H. Influenza) etc is infection factors.The infection factors affect stableness of atherosclerotic plaque.Cytokine(TNF、IL-6、CRP) and adhesion molecule induce vascular cell injury. Application of the antibotic in the treatment of CHD has achieved some progress.In this article, the progress in this field are summarized. |
| Key words: Coronary Heart Disease Infection Antibotic |
