| 摘要: |
| ［摘要］ 脂蛋白脂酶(LPL)是富含甘油三酯脂蛋白代谢的关键酶，其基因突变影响LPL活性，造成甘油三酯(TG)水平升高和高密度脂蛋白（HDL）水平降低，导致脂代谢紊乱，与冠心病、肥胖高血压、2型糖尿病及慢性肾脏疾病有一定的相关性，但就目前的研究看来，结果存在差异，一些问题还需进一步阐明。 |
| 关键词: 脂蛋白脂酶 冠心病 肥胖高血压 2型糖尿病 慢性肾脏疾病 |
| DOI：10.3969/j.issn.1674-3806.2009.05.034 |
| 分类号:R 541.4 |
| 基金项目: |
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| Research on relationship between lipoprotein lipase and related diseases |
|
ZHOU Wei-ya
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The People Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Lipoprotein Lipase (LPL) is a key enzyme of lipoprotein metabolism. Its gene mutant influences LPL′s activity and increase triglyceride (TG) level while lowering high-density lipoprotein (HDL) level, which results in lipid metabolic disorder. These are considered to contribute to some diseases like coronary atherosclerotic heart disease, obesity-related hypertension and type2 diabetes and chronic kidney disease.But research results differ at present and a number of issues are left to be further clarified. |
| Key words: Lipoprotein Lipase Coronary atherosclerotic heart disease Obesity-related hypertension Type2 diabetes Chronic kidney disease |
